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Clinical Trials/NCT05533047
NCT05533047UnknownNot Applicable

Serum Prostatic Specific Antigen (PSA) Changes After Bipolar and Monopolar Transurethral Resection of the Benign Prostatic Hyperplasia, a Randomized Controlled Study.

Assiut University0 sites2 target enrollmentStarted: October 1, 2022Last updated:
Conditions
Interventions

Trial Snapshot

Phase
Not Applicable
Enrollment
2
Primary Endpoint
serum PSA changes after bipolar and monopolar transurethral resection of the benign prostatic hyperplasia

Study Overview

Brief Summary

To use PSA levels after bipolar and monopolar transurethral resection of the benign prostatic hyperplasia as an indicator of the quality of resection .

Detailed Description

PSA is a protein produced from the prostate epithelium and secreted in semen in huge amounts , small amount find its way to the circulation ,its function is to allow mobility of the sperms by interacting with the Semenogelin . clinical BPH can be defined as prostate adenoma/adenomata, causing a varying degree of BOO, which may eventually cause harm to the patients ,Treatment of this condition varies from conservative, medical and surgical depending on factors related to the patient and the surgeon preference . The early reports of minimally invasive treatment of the prostate dated back to 1937, since then and remarkable development is noticed . TURP is the golden treatment in the BPH . Studies compare between the methods according the blood transfusion , operation time retention after catheter removal , urethral complications , TUR syndrome and hospital-stay which show that bipolar is better. To our knowledge after few studies compare between the techniques according PSA also these studies show weakness in their statistically analysis with no difference between the methods .investigators aim is to study the effect of the operations on PSA levels as an indicator of the quality of resection.

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel
Primary Purpose
Other
Masking
Single (Participant)

Eligibility Criteria

Ages
50 Years to 80 Years (Adult, Older Adult)
Sex
Male
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •Patients agreeing to participate, clinically fit, age from 50 to 80 years with LUTS related to benign prostate enlargement with no neurological disorder

Exclusion Criteria

  • •Prostate cancer
  • •Previous urethral or prostate surgery
  • •Neurogenic bladder
  • •Urethral stricture
  • •Patient unfit for surgery

Arms & Interventions

Bipolar TURP

Active Comparator

Patients thats will undergo bipolar TURP

Intervention: TURP (Procedure)

Monopolar TURP

Active Comparator

Patients thats will undergo monopolar TURP

Intervention: TURP (Procedure)

Outcomes

Primary Outcomes

serum PSA changes after bipolar and monopolar transurethral resection of the benign prostatic hyperplasia

Time Frame: within one month after intervention

To use PSA levels changes after both techniques (bipolar and monopolar transurethral resection of the benign prostatic hyperplasia)as an indicator of the quality of resection

Secondary Outcomes

  • International Prostate Symptom Score(within one month after intervention)

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Andrew Hamam Wahba Gerges

Principal Investigator

Assiut University

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