NCT00685191已完成4 期
HIV-1 Viral Dynamics in Subjects Initiating Raltegravir Therapy in Spain
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- Change in viral load from day 0 to 7
研究概览
简要总结
The study purpose is to investigate plasma HIV-1 RNA dynamics in subjects initiating raltegravir-based salvage therapy and quantify the corresponding changes in levels of cellular HIV-1 DNA.
详细描述
First- and second-phase decay rates of plasma HIV-1 RNA and changes in the intracellular levels of HIV-1 proviral DNA and LTR circles will be measured in subjects starting salvage antiretroviral therapy including raltegravir in Spain.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who have limited or no treatment options due to extensive antiretroviral drug resistance or drug intolerance.
- •Subjects initiating raltegravir plus another fully active antiretroviral drug.
排除标准
- •Pregnancy, or fertile women willing to be pregnant.
- •Active substance abuse or major psychiatric disease.
研究组 & 干预措施
1
Experimental
HIV-1-infected subjects initiating raltegravir-including salvage therapy
干预措施: Salvage antiretroviral therapy including raltegravir (Drug)
结局指标
主要结局
Change in viral load from day 0 to 7
时间窗: 1 week
次要结局
- Intracellular levels of HIV-1 proviral DNA and LTR circles(24 weeks)
研究者
研究点 (1)
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