JPRN-UMIN000009958已完成未知
Effects of donepezil on the prognosis of Parkinson's disease with severe olfactory dysfunction - Effects of donepezil on the prognosis of Parkinson's disease with severe olfactory dysfunction
ational Hospital Organization, Sendai-Nishitaga Hospital0 个研究点目标入组 200 人开始时间: 2013年3月1日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 200
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 55years-old 至 75years-old（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •1) Patients with a history of other neurological and/or psychological disorders which may influence motor and cognitive function 2) Patients with the presence of apparent local lesions on head MRI (Note that brain atrophy and white matter ischemia are granted as age-related physiological observation) 3) Patients who had taken anticholinergic drug or drug with an anticholinergic effect within 4 weeks prior to the registration 4) Patients with a symptom such as rhinitis and sinusitis which was considered to affect olfactory sense 5) Patients who need a treatment for depression, the score of >=3 in "1.3. Depressed Mood", the Japanese version of the MDS-UPDRS 6) Patients suspected of impairment in cognitive function (MMSE embedded in the ACE-R <26, or CDR >=1) 7) Patients with a history of hypersensitivity to Donepezil hydrochloride or piperidine derivative 8) Patients with complications of cardiac diseases such as sick sinus syndrome, conduction disturbance in intra-atrial and atrioventricular junction (e.g., sinoatrial block, second- or higher degree atrioventricular block) 9) Patient with a history of severe peptic ulcer 10) Patients with complications of or a history of severe bronchial asthma or obstructive pulmonary disease 11) Patients with a history of stereotaxic surgery or deep brain stimulation 12) Patient who were judged inappropriate for this study by doctors
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