The Use of Angiotensin Converting Enzyme Inhibitors and Incident Respiratory Infections, Are They Harmful or Protective?
- Conditions
- Covid-19, Coronavirus, Angiotensin Converting Enzyme Inhibitors, Influenza, Electronic Health Records, Epidemiology, Comorbidity, Incidence, United Kingdom
- Interventions
- Drug: ACE inhibitor
- Registration Number
- NCT04322786
- Lead Sponsor
- University College, London
- Brief Summary
The study use UK based linked electronic health records from the Clinical Research Datalink (CALIBER) of 5.6 million individuals to conduct a matched case-control study to investigate the incidence of influenza in individuals prescribed ACEI compared to those not prescribed ACEI.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 1302508
Inclusion Criteria
- We identify individuals aged 18 years or older and registered in the current primary care practice for at least one year.
Exclusion Criteria
- We exclude individuals with a prior history of influenza and viral pneumonia before study entry.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description ACEI user ACE inhibitor Individuals with an ACEI prescription in the study population.
- Primary Outcome Measures
Name Time Method Incidence of influenza Jan 1st 1998 - May 31st 2016
- Secondary Outcome Measures
Name Time Method