Dynamic Neural Mechanisms of Audiovisual Speech Perception
Overview
- Phase
- Early Phase 1
- Intervention
- Not specified
- Conditions
- Speech Perception
- Sponsor
- University of Pennsylvania
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Measurement of neural activity
- Status
- Enrolling By Invitation
- Last Updated
- 7 months ago
Overview
Brief Summary
Understanding speech is one of the most important functions of the human brain. We use information from both the auditory modality (the voice the of person we are talking to) and the visual modality (the facial movements of the person we are talking to) to understand speech. We will use intracranial encephalography to study the organization and operation of the brain during audiovisual speech perception.
Investigators
Michael Beauchamp, PhD
Professor
University of Pennsylvania
Eligibility Criteria
Inclusion Criteria
- •must be undergoing neurosurgery for the treatment of a brain disorder
Exclusion Criteria
- •must have corrected-to-normal vision and hearing
Outcomes
Primary Outcomes
Measurement of neural activity
Time Frame: During the procedure.
The name of the measurement is the broadband high-frequency activity (BHA) in the brain in response to audiovisual speech. The unit of measure is % increase in power from pre-stimulus baseline. The name of the measurement tool is intracranial EEG, recordings of the raw voltage signal from each electrode implanted in the brain. The voltage-by-time signal will be converted to spectral space using a wavelet transform, and the magnitude of the power between 70 and 150 Hz inclusive in a time window between 0 ms and 500 ms after stimulus onset will be calculated.