Thrombin Generation after Abrupt Cessation versus Weaning over 8 hours of Continuous Infusion of Unfractionated Heparin in ICU-patients after Discontinuation of Continuous Venovenous Hemofiltration.

Completed

• Conditions: Aburpt cessation of continuous intravenous treatment with Unfractionated Heparin.

• Registration Number: NL-OMON21886
• Lead Sponsor: none

Brief Summary

/A

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

1. Patients scheduled to stop treatment with CVVH because they no longer require it (physicians discretion/local protocol);

2. Age >18 years;

Exclusion Criteria

1. Patients with known coagulation disorders;

2. Patients receiving any anti-coagulant treatment for reasons other than CVVH.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Thrombin-Antithrombin complexes (TATc).

Secondary Outcome Measures

Name	Time	Method
aPTT, anti-Xa, factor VII/VIIa, TF, TFPI-antigen, TFPI activity, protein C / activated protein C, aPC-sr, prothrombine fragment 1.2, ETP (Endogenous Thrombin Potential), Fibrin monomers, soluble thrombomodulin, PAPc, PAI.