Multiple Sclerosis Produces Cardiovascular Subclinical Dysfunction
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 103
- 主要终点
- Left ventricle systolic dysfunction - by echocardiography
研究概览
简要总结
Multiple sclerosis (MS), debilitating disease involving primarily the central nervous system, may cause cardiovascular dysfunction, due to autonomous nervous system dysfunction, physical invalidity, increased oxidative stress, and systemic inflammatory status, but the detailed mechanisms are not elucidated. The investigators aimed to assess left and right ventricular (LV and RV) function, left atrial (LA) function, arterial function, and atrial-ventricular-arterial coupling in patients with MS, compared to control subjects. LV systolic and diastolic function and RV function were assessed by 2D- and 3D- echocardiography, tissue Doppler, and speckle tracking echocardiography. LA function was assessed by LA volume index and LA strain. Arterial remodeling and stiffness were assessed by intima media-thickness, pulse wave velocity, and parameters of wave intensity and endothelial function
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age between 18 and 65 years;
- •patients with confirmed MS diagnosis, both newly diagnosed or already under immunomodulatory treatment;
- •informed consent signed.
排除标准
- •MS treated with mitoxantrone;
- •patients with known cardiovascular disease;
- •presence of other neurological conditions;
- •any renal, pulmonary, hepatic or hematological disease;
- •diabetes mellitus;
- •any degree of arterial hypertension;
- •and difficult acoustic window
结局指标
主要结局
Left ventricle systolic dysfunction - by echocardiography
时间窗: 1 year
Left ventricular diastolic function - by echocardiography
时间窗: 1 year
arterial function - by vascular echography
时间窗: 1 year
Right ventricle systolic dysfunction- by echocardiography
时间窗: 1 year
次要结局
未报告次要终点
研究者
Raluca Mincu
Dr
Carol Davila University of Medicine and Pharmacy