CTRI/2021/01/030256
Not yet recruiting
未知
Maintenance metronomic chemotherapy following standard surgery and adjuvant treatment in locally advanced oral Squamous cell carcinoma.
Dr Naveena Kumar A0 sites0 target enrollmentTBD
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Health Condition 1: C148- Malignant neoplasm of overlappingsites of lip, oral cavity and pharynx
- Sponsor
- Dr Naveena Kumar A
- Status
- Not yet recruiting
- Last Updated
- 4 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Locally advanced primary oral SCC who underwent curative surgery (pT3 and above, pN1 and above).
- •2\. Age more than 18 years.
- •3\. Patients with normal organ and marrow function as below
- •a. Hemoglobin \> 8 g/L
- •b. Total WBC \>\= 3000/mcL or Absolute neutrophil count (ANC) \> 1\.5 x 109/L
- •c. Platelets \>\= 100000/mcL
- •d. Total bilirubin \< 2 Ã? institutional upper limit of normal
- •e. AST(SGOT)/ALT(SGPT) \<\=2\.5 Ã? institutional upper limit of normal
- •f. Adequate renal function with Creatinine clearance \> 30 ml/min
Exclusion Criteria
- •1\. Early SCC oral cavity (pT1, pT2, pN0\)
- •2\. Patient with locally advanced SCC oral cavity, who have not received standard surgery and/or adjuvant treatment.
- •3\. Recurrent/second primary oral malignancy
- •4\. Age more than 80 years
- •5\. Pregnant women
- •6\. Patient not fit for Metronomic chemotherapy
- •7\. Patients with QTc prolongation defined as QTc interval greater than 0\.5 seconds (celecoxib associated sudden cardiac death)
- •8\. Patient not giving informed consent
Outcomes
Primary Outcomes
Not specified
Similar Trials
Not yet recruiting
Phase 2
Chemoradiation followed by maintenance therapy for patients with locally advanced cutaneous angiosarcomaCutaneous angiosarcomaJPRN-UMIN000014397niversity of Tsukuba60
Active, not recruiting
Phase 1
Metronomic chemotherapy in elderly non-fit patients with aggressive B-Cell lymphomas. Phase II studyB-Cell lymphomasMedDRA version: 21.0Level: LLTClassification code 10012855Term: Diffuse large cell lymphoma (Diffuse large B-cell lymphoma) (Working Formulation)System Organ Class: 100000004864Therapeutic area: Diseases [C] - Blood and lymphatic diseases [C15]EUCTR2016-003703-62-ITFONDAZIONE ITALIANA LINFOMI ONLUS60
Recruiting
Phase 2
PhaseII study of maintenance S-1 after chemotherapy with platinium+pemetrexed in advanced nonsquamous NSCLC.on Squamous Non Small Cell Lung CancerJPRN-UMIN000009275Kansai Medical University22
Active, not recruiting
Phase 1
Phase 2 trial evaluating metronomic chemotherapy in patients with relapsed or refractory Wilms tumorEUCTR2021-002540-67-FRCentre Oscar Lambret28
Not yet recruiting
Not Applicable
Music therapy for chemotherapy induced nausea and vomitingACTRN12622001495718Flinders Foundation24