Maintenance metronomic chemotherapy following standard surgery and adjuvant treatment in locally advanced oral Squamous cell carcinoma.

Dr Naveena Kumar A0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

研究概览

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•1. Locally advanced primary oral SCC who underwent curative surgery (pT3 and above, pN1 and above).
•2. Age more than 18 years.
•3. Patients with normal organ and marrow function as below
•a. Hemoglobin > 8 g/L
•b. Total WBC >= 3000/mcL or Absolute neutrophil count (ANC) > 1.5 x 109/L
•c. Platelets >= 100000/mcL
•d. Total bilirubin < 2 Ã? institutional upper limit of normal
•e. AST(SGOT)/ALT(SGPT) <=2.5 Ã? institutional upper limit of normal
•f. Adequate renal function with Creatinine clearance > 30 ml/min

•1. Early SCC oral cavity (pT1, pT2, pN0)
•2. Patient with locally advanced SCC oral cavity, who have not received standard surgery and/or adjuvant treatment.
•3. Recurrent/second primary oral malignancy
•4. Age more than 80 years
•5. Pregnant women
•6. Patient not fit for Metronomic chemotherapy
•7. Patients with QTc prolongation defined as QTc interval greater than 0.5 seconds (celecoxib associated sudden cardiac death)
•8. Patient not giving informed consent

发起方

Dr Naveena Kumar A