NCT00015080已完成2 期
Naltrexone in Treatment of Cocaine Dependence
适应症
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 试验地点
- 2
- 主要终点
- Retention
研究概览
简要总结
The purpose of this study is to determine the efficacy of naltrexone in the treatment of cocaine dependence as measured by: 1) decreased urine benzoylecgonine (BE) levels, 2) decreased cocaine use by self-report, 3) decreased cocaine craving, and 4) retention in treatment.
详细描述
Double-blind, placebo controlled study of the safety and efficacy of naltrexone in treating cocaine dependence in a patient sample that initiated the study while in an inpatient setting and were then followed-up for 3 months as outpatients.
研究设计
- 研究类型
- Interventional
- 主要目的
- Treatment
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Meet DSM-III-R criteria for cocaine dependency,
- •18 to 65 years of age,
- •capable of understanding the study,
- •voluntarily signed consent,
- •male or non-pregnant female using approved form of birth control.
排除标准
- •abnormal liver function tests (SGOT, SGPT, or GGT greater than twice the normal values),
- •opioid use within the last 7 days,
- •use of neuroleptics,
- •having a severe acute medical problem,
- •unable to complete psychiatric rating scales, or
- •judged by the investigator to be unlikely to comply with the study protocol
结局指标
主要结局
Retention
Global improvement
Psychopathology
Cocaine use
Depression
Anxiety
Addiction severity
次要结局
未报告次要终点
研究者
研究点 (2)
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