Hepatic Mitochondrial Function in Sepsis

Withdrawn

• Conditions: Peritonitis; Sepsis

• Registration Number: NCT00889083
• Lead Sponsor: Professor C ICHAI

Brief Summary

Multi-organ failure due to sepsis is a major cause of death in critically ill patients. But the mechanisms leading to this condition are not fully understood. Mitochondrial dysfunction has been shown in skeletal muscle of critically ill septic patients. Liver is very important in sepsis as it is responsible of the synthesis of several inflammatory proteins. Moreover hepatic failure is associated to a bad outcome.

The aim of this study is to evaluate the hepatic mitochondrial function in sepsis.

Detailed Description

Not available

Study Timeline

• Study Start: 2009-04
• Study First Submitted: 2009-04-24
• Study First Submitted QC: 2009-04-27
• Study First Posted: 2009-04-28
• Primary Completion: 2012-04
• Study Completion: 2012-04
• Status Verified: 2020-07
• Last Update Submitted: 2020-07-29
• Last Update Posted: 2020-07-31

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Septic group : Peritonitis patients needing surgery
• Non septic group : Patients needing hepatic surgery

Exclusion Criteria

• No liver biopsy performed

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mitochondrial complex activities	during surgery

Secondary Outcome Measures

Name	Time	Method
Quantification of adenine nucleotides	during surgery
Quantification of oxidative stress markers	during surgery
Correlation between SOFA score and mitochondrial complex activities	28 days

Trial Locations

Locations (1)

CHU de Nice; 🇫🇷 Nice, France