Imaging of Ventricular Reversed Remodeling after Double Lung Transplantation in Patients with Pulmonary Arterial Hypertensio

Completed

Conditions: high blood pressure pulmonary artery
Idiopathic/primary pulmonary arterial hypertension
10019280
10037454

Registration Number: NL-OMON41137

Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 20

Inclusion Criteria

Primary study group:
- Patients who are on the waiting list for double-LTX, in our institution, for pulmonary arterial hypertension
- Eligible for CMR imaging
- No claustrophobia
- No pacemaker, ICD, etc.
- Informed consent;Control group:
- Patients who are on the waiting list for double-LTX, in our institution.
- Echocardiographic evaluation including an estimation of RV peak pressure, <35 mmHg.
- Eligible for CMR imaging
- No claustrophobia
- No pacemaker, ICD, etc.
- Informed consent

Exclusion Criteria

- Inability to comply with primary endpoint measures.
- Body mass index >40 kg/m2.
- Pregnant patients will not be included, they may be included >3 months after pregnancy.
- Patients with age <18 years

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Right ventricular remodeling measured on cardiac magnetic resonance (CMR)<br /><br>imaging after LTX will be investigated in terms of: 1) RV mass,<br /><br>trabecularisation and extracellular matrix composition; 2) geometry and septal<br /><br>configuration; 3) radial, circumferential and longitudinal deformation. Left<br /><br>ventricular remodeling comprises function, geometry and mass.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Functional parameters on echocardiography, disease specific<br /><br>electrophysiological findings on electrocardiography (ECG) and N-terminal<br /><br>probrain natriuretic peptide (NT pro-BNP) level.</p><br>