The Incidence of Venous Thromboembolism in Atopic Dermatitis: A Matched Cohort Analysis in UK Primary Care
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 754,745
- 试验地点
- 1
- 主要终点
- Number of Participants With Diagnosis of Venous Thromboembolism After the Start of Follow-up for Each Person.
研究概览
简要总结
This study aims to investigate the incidence of venous thromboembolism in people who are diagnosed with atopic dermatitis.
详细描述
The aim of this study is to examine whether venous thromboembolism is higher in people with atopic dermatitis compared and those without and to explore the risk in particular subgroups of people with AD such as those with higher body mass index or using oestrogen containing contraceptives. Such insights will be valuable for clinicians in advising patients with atopic dermatitis regarding venous thromboembolism prevention and detection and when selecting atopic dermatitis treatments.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All eligible adult people (aged ≥ 18) registered with GP practices contributing data to OPCRD between January 1, 2010 and January 1, 2020, were eligible for inclusion in the study.
排除标准
- •People with less than 5 years potential follow up. People with atopic dermatitis that was not active atopic dermatitis during the study period. People without atopic dermatitis but diagnosed with other skin conditions.
结局指标
主要结局
Number of Participants With Diagnosis of Venous Thromboembolism After the Start of Follow-up for Each Person.
时间窗: 10 years from index date
To describe the risk of venous thromboembolism (composite of pulmonary embolism and deep vein thrombosis) in people with active AD compared to a matched control population.
次要结局
- Number of Participants With Diagnosis of Pulmonary Embolism After the Start of Follow-up for Each Person(10 years from index date)
- Number of Participants With Diagnosis of Deep-vein Thrombosis After the Start of Follow-up for Each Person(10 years from index date)
- Number of Male Participants With Diagnosis of Risk of Venous Thromboembolism After the Start of Follow-up for Each Person(10 years from index date)
- Number of Female Participants With Diagnosis of Risk of Venous Thromboembolism After the Start of Follow-up for Each Person(10 years from index date)
- Number of Participants Aged 18-44 With Diagnosis of Venous Thromboembolism After the Start of Follow-up for Each Person(10 years from index date)
- Number of Participants Aged 45-64 With Diagnosis of Venous Thromboembolism After the Start of Follow-up for Each Person(10 years from index date)
- Number of Participants Aged ≥65 With Diagnosis of Venous Thromboembolism After the Start of Follow-up for Each Person(10 years from index date)
- Number of Participants BMI <30 With Diagnosis of Venous Thromboembolism After the Start of Follow-up for Each Person(10 years from index date)
- Number of Participants BMI ≥30 With Diagnosis of Venous Thromboembolism After the Start of Follow-up for Each Person(10 years from index date)
- Number of Female Participants Aged 18-44 Using Oestrogen Contraceptive With Diagnosis of Venous Thromboembolism After the Start of Follow-up for Each Person(10 years from index date)
- Number of Participants Having History of an Allergic Condition With Diagnosis of Venous Thromboembolism After the Start of Follow-up for Each Person(10 years from index date)