Validation Externe Par Apprentissage Statistique et réduction Des Dimensions d'entrée de l'échelle D-PSY
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Prediction of SCID-5
研究概览
简要总结
There have been debates about whether psychiatric disorders should be classified according to categories (categorical model) or according to a continuum between normal and pathological functioning (dimensional model). While the former is the main one used to facilitate reliability, it has several limitations. We will use machine learning to develop a predictive model, bridging the gap between the dimensional and categorical approaches. Psychometric measures obtained from a questionnaire will be collected. Then, a supervised descriptor selection approach will be applied to predict categorical outcomes from dimensional inputs. The resulting prediction will be based on nonlinear modeling based on universal approximators. We developed this input questionnaire with four main objectives: 1) to briefly scan most of the categories generally described in the international nosography; 2) to use a continuous scale following a dimensional approach; 3) to use positively oriented sentences to decrease social desirability bias; 4) to be less confronting for the patient.
The questionnaire is built on dimensions, whereas psychiatric diagnoses are built on categories. We will model the transition from one to the other. This approach will allow us to verify the hypotheses of diagnostic categories construction in psychopathology, integrated in the RDoC approach; and later on to standardize the psychometric measures used in cognitive-behavioral therapy treatments.
200 adults will undergo a standard clinical interview (SCID-5, First et al., 2017), and the psychological screening self-report questionnaire (D-Psy) and additional questionnaires measuring social desirability dissociation, phobia and autism.
详细描述
This is a pilot study, in which 200 participants, aged 18-55 years, taken from the general population, with suspected psychopathology, will participate in screening consultations in which symptoms will be assessed with three different psychometric diagnostic tools. Their symptoms will be assessed using the French version of the SCID-5 (First et al., 2017), and the D-PSY screening procedure, including a self-reported questionnaire and semiological observations. Supplemental questionnaires will also be administered. The order in which these diagnostic tools will be administered will be randomized. Participants will be recruited in France, where the research will take place.
Doctors in the vicinity of the institute will be contacted and the study will be explained to them so that they can suggest eligible patients to participate. Advertising like posters presenting the study will also be put up in health care center and specialized websites. When a person agrees to participate in the study, they will be given an information letter about the protocol. After a delay of reflection, patients who agree to perform this research will be convened for an inclusion visit. After checking the inclusion/exclusion criteria, the letter of information will be completed and signed by the participant and duly countersigned by the investigator.
During this inclusion visit, a history will be taken in which demographic, psychiatric/medical data will be collected. Following this interview, the trained practitioner will complete his or her semiological observations of the patient.
The assessment phase includes the SCID-5 (First et al., 2017), the D-PSY questionnaire and standardized questionnaires. The D-PSY questionnaire and the SCID-5 (First et al., 2017) will be counterbalanced in terms of the order of administration, with half of the participants taking the SCID-5 (First et al., 2017) first and then the D-PSY questionnaire and the others standardized; the other half will take the D-PSY first and then the SCID-5 (First et al., 2017) and the other questionnaires.
The SCID-5 interview will be conduct by a practitioner familiar with this interview and with the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5, American Psychiatric Association, 2013) classification and diagnostic criteria. Mental health practitioners administering the interviews will be blinded to the questionnaire scores.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adults over 18 years old and less than 65 years old who are fluent in French (oral and written), with suspicions of psychopathology.
- •Protected adults and pregnant women cannot participate.
排除标准
- •Participant with neurological or organic mental disorder (not induced by substances) including dementia, organic amnesic syndrome, delirium;
- •other mental, personality or behavioural disorders due to brain damage, dysfunction or to physical disease.
结局指标
主要结局
Prediction of SCID-5
时间窗: 1 year
Predict the majority of SCID-5 pathologies (validity test) with a success rate significantly higher than chance.
次要结局
- Desirability bias(18 monthes)
- Non-confrontational questionnaire(18 monthes)
- Dimensional structure of psychopathologies(2 years)
- Ease-of-use(18 monthes)