The Effects of Azithromycin Ophthalmic Solution, 1% Versus Placebo in Subjects With Blepharitis During a Two-Week Treatment Period
- Conditions
- Blepharitis
- Interventions
- Drug: Azithromycin ophthalmic solution, 1%Drug: Placebo
- Registration Number
- NCT00892970
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Brief Summary
The objective of this study is to compare the safety and efficacy of azithromycin ophthalmic solution, 1% versus placebo over a two-week treatment period.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 313
- Have best corrected visual acuity in both eyes of at least +0.7 or better
- If female, are non-pregnant or non-lactating
- Have a current diagnosis of blepharitis in one or both eyes
- Have lid structural abnormalities
- Have suspected ocular fungal or viral infection
- Have practiced warm compress therapy within 14 days prior to Visit 2
- Unable to withhold the use of contact lenses during the treatment or follow-up periods
- Unable to withhold the use of ocular cosmetic products within 24 hours prior to study visits
- Have had penetrating intraocular surgery within 90 days prior to Visit 2
- Have had ocular surface surgery within the past year prior to Visit 2
- Have a serious medical condition which could confound study assessments
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 1 Azithromycin ophthalmic solution, 1% - 2 Placebo -
- Primary Outcome Measures
Name Time Method Eyelid margin erythema Two weeks
- Secondary Outcome Measures
Name Time Method Signs and symptoms of Blepharitis One week, two weeks, three weeks, four weeks
Trial Locations
- Locations (33)
Ophthalmology Associates
🇺🇸St. Louis, Missouri, United States
Wilmer Eye Institute, Johns Hopkins Hospital
🇺🇸Baltimor, Maryland, United States
Milton Hom, OD
🇺🇸Azusa, California, United States
The Jules Stein Eye Institute UCLA Laser Refractive Center
🇺🇸Los Angeles, California, United States
David Wirta, MD, Inc.
🇺🇸Newport Beach, California, United States
NorthShore University HealthSystems
🇺🇸Glenview, Illinois, United States
Indiana University School of Medicine, Ophthalmology Dept.
🇺🇸Indianapolis, Indiana, United States
Wolstan Eye Associates
🇺🇸Torrence, California, United States
TLC Laser Eye Center
🇺🇸Greensboro, North Carolina, United States
Eye Physicians and Surgeons, LLP
🇺🇸Iowa City, Iowa, United States
North Bay Eye Associates
🇺🇸Petaluma, California, United States
See Clearly Vision Group
🇺🇸McLean, Virginia, United States
Ophthalmology Consultants
🇺🇸St. Louis, Missouri, United States
Bucci Laser Vision Institute
🇺🇸Wilkes-Barre, Pennsylvania, United States
West Coast Eye Care
🇺🇸San Diego, California, United States
Koffler Vision Group
🇺🇸Lexington, Kentucky, United States
North Valley Eye Medical Group
🇺🇸Mission Hills, California, United States
Minnesota Eye Consultants
🇺🇸Minneapolis, Minnesota, United States
Eye Clinic of Austin
🇺🇸Austin, Texas, United States
Virginia Eye Consultants
🇺🇸Norfolk, Virginia, United States
Brar-Parekh Eye Associates
🇺🇸West Paterson, New Jersey, United States
Eye Centers of Florida
🇺🇸Fort Myers, Florida, United States
Ophthalmic Consultants of Boston
🇺🇸Boston, Massachusetts, United States
South Shore Eye Care
🇺🇸Wantagh, New York, United States
Mundorf Eye Center
🇺🇸Charlotte, North Carolina, United States
Jones Eye Institute
🇺🇸Little Rock, Arkansas, United States
Eye Center - A Medical and Surgical Group
🇺🇸Hamden, Connecticut, United States
Abrams Eye Center
🇺🇸Cleveland, Ohio, United States
Florida Eye Microsurgical Institute
🇺🇸Boynton Beach, Florida, United States
Sall Medical Research Center
🇺🇸Artesia, California, United States
Chicago Cornea Consultants
🇺🇸Hoffman Estates, Illinois, United States
Cornerstone Eye Care
🇺🇸High Point, North Carolina, United States
McCabe Vision Center
🇺🇸Murfreesboro, Tennessee, United States