JPRN-UMIN000005525已完成未知
Phase I Trail of pegylated liposomal doxorubicin (PLD) in combination with Irinotecan (CPT-11) in Patients with Platinum Refractory and Resistant Ovarian cancer - Phase I Trail of pegylated liposomal doxorubicin (PLD) in combination with Irinotecan (CPT-11) in Patients with Platinum Refractory and Resistant Ovarian cancer
Fukuoka University, School of Medicine0 个研究点目标入组 6 人开始时间: 2011年5月1日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 6
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 20years-old 至 75years-old（—）
- 性别
- Female
入选标准
- 未提供
排除标准
- •1) Patients with severe complications or active infection. 2) Patients with prior diagnosis of malignancy are not eligible. Exceptions are(non-melanoma skin cancer, and carcinoma in situ.-other malignancies curatively treated and > 5 years without evidence of recurrence) 3) Patients with massive pleural effusion and/or ascites. 4) Patients with massive pericardial fluid. 5) Patients with unstable angina or those who have had a myocardial infarction within the past 90 days. 6) Patients with brain metastasis who have symptoms or require administration of steroid or antihydropic. 7) Patients with bowel paralysis or obstruction. 8) Patients with diarrhea or watery stool. 9) Patients with apparent interstitial pneumonitis or pulmonary fibrosis 10) Patients who have received prior bone marrow transplantation, or high-dose chemotherapy and hematopoietic stem cell transplantation. 11) Patients who have received prior chemotherapy consisting of pegylated liposomal doxorubicin. 12) Patients who have participated in other clinical trials. 13) Patients with history of hypersensitivity reactions to doxorubicin or irinotecan or the components of pegylated liposomal doxorubicin. 14) Patients who are pregnant, lactating, and have pregnant possibility or intention. 15) Patients who are decided to be ineligible for this trial by the investigators.
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