Role of B2 Adrenergic Receptors in Labor Pain

Completed

• Conditions: Pain; Labour Pain; Pain Threshold

• Registration Number: NCT00385294
• Lead Sponsor: Columbia University

Brief Summary

The study aims to understand why labor is more painful for some women compared to others. The study will study whether a woman's baseline pain sensitivity, beta2 adrenergic receptor genotype is related to her pain in labor for the birth of a first child.

Detailed Description

Other than parity, and infant size, the etiology of the great variability in labor pain us unknown. Previous studies have demonstrated that baseline pain sensitivity is related to postoperative pain and narcotic requirement. We hypothesize that baseline pain sensitivity is related to pain in labor. The study will determine baseline sensitivity to heat, cold and pressure as measurement of pain sensitivity. Furthermore, b2 adrenergic genotype has recently been identified as a potential determinant of pain sensitivity. The investigators will determine whether B2 receptor haplotype is an independent predictor of pain experienced in labor.

Study Timeline

• Study Start: 2006-09
• Study First Submitted: 2006-10-05
• Study First Submitted QC: 2006-10-05
• Study First Posted: 2006-10-09
• Primary Completion: 2009-01
• Study Completion: 2009-01
• Status Verified: 2018-07
• Last Update Submitted: 2018-07-16
• Last Update Posted: 2018-07-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 150

Inclusion Criteria

• nulliparous women
• Third trimester of pregnancy on enrollment

Exclusion Criteria

• Chronic Pain
• Pain medication utilization
• Large for gestational age baby
• Small for gestational age baby
• Systemic illness

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Columbia University; 🇺🇸 New York, New York, United States