A Phase II Trial of Hypofractionated Radiotherapy Combined With Thymosin for Metastatic NSCLC Patients Who Showed Stable Disease After First Line TKI Therapy
Overview
- Phase
- Phase 2
- Intervention
- TKI
- Conditions
- Lung Adenocarcinoma
- Sponsor
- First People's Hospital of Hangzhou
- Enrollment
- 46
- Locations
- 1
- Primary Endpoint
- The proportion of patients with an abscopal response assessed at 1-6 months after the radiation therapy
- Last Updated
- 9 years ago
Overview
Brief Summary
The investigators postulated that the exploitation of the pro-immunogenic effects of radiotherapy with thymosin might result in abscopal responses among patients with metastatic cancer. The research is designed to evaluate the efficacy and toxicity of patients treated with hypofractionated radiotherapy combined with thymosin alpha 1. An exploratory biomarker analysis in blood and tumor samples is also planned.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Newly diagnosed metastatic lung adenocarcinoma harboring sensitizing EGFR mutations (L858R, exon 19 deletion), and showed stable disease after 3 months TKI, evaluated twice by PET/CT scan, brain MRI, and abdomen ultrasound (≥3 measurable lesions, and these lesions haven't received local therapy)
- •Age 18 years or older
- •ECOG Performance Status 0-2
- •Adequate bone marrow, liver and renal function, as specified below: Absolute Neutrophil Count (ANC) ≥ 1.5 x 109/L; Hemoglobin ≥ 8 g/dL; Platelets ≥ 100 x 109/L; Serum total bilirubin ≤ 1.5 x upper limit of normal (ULN) ; AST and ALT ≤ 2.5 x ULN or ≤ 5 x ULN if liver metastases are present; Serum creatinine ≤ 1.5 x upper limit of normal or creatinine clearance ≥ 60ml/min for patients with creatinine levels above institutional normal
- •For women of child-bearing potential, negative pregnancy test within 14 days prior to starting treatment
- •Men and women of childbearing age must be willing to use effective contraception while on treatment and for at least 3 months thereafter
- •Patients and their family signed the informed consents
Exclusion Criteria
- •Received chemotherapy before TKI therapy
- •Brain parenchyma or leptomeningeal disease
- •Concurrent malignancies other than non-melanoma skin cancer that require active ongoing treatment
- •Any medical co-morbidities that would preclude radiation therapy.
Arms & Interventions
1
After 3 mos TKI, patients showed stable disease take TKI, radiotherapy and thymosin alpha 1 till tumor progression.
Intervention: TKI
1
After 3 mos TKI, patients showed stable disease take TKI, radiotherapy and thymosin alpha 1 till tumor progression.
Intervention: Thoracic Hypofractionated Radiotherapy
1
After 3 mos TKI, patients showed stable disease take TKI, radiotherapy and thymosin alpha 1 till tumor progression.
Intervention: Thymosin Alpha 1
Outcomes
Primary Outcomes
The proportion of patients with an abscopal response assessed at 1-6 months after the radiation therapy
Time Frame: 1-6 months
To assess the proportion of patients with an abscopal response (defined as at least a 30% decrease in the longest diameter of the best responding abscopal lesion) at 1-6 months after the radiation therapy
Secondary Outcomes
- To assess the short-term quality of life (QOL)(4 months)
- Rate of CTCAE grade 2 or higher radiation pneumonitis(1 years)
- Overall Survival(2 years)