Effect of omega-3 on metabolic and inflammatory indices in patients with chronic schizophrenia
- Conditions
- Schizophrenia.Schizophrenia
- Registration Number
- IRCT201603095280N23
- Lead Sponsor
- Vice chancellor for research, Mashhad University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 56
patients with schizophrenia admitted in Hejazi and Ibn Sina hospital in Mashhad that treated with clozapine and valproate at least 3 months (clozapine dose of 200 to 400 mg); Age 18 years or older; triglyceride levels in the morning between 200 to 499 Milligrams per deciliter; metabolic indices of patients before starting treatment with clozapine and valproate are normal. Exclusion criteria: Pregnancy or Lactation; history of sensitivity to fish oil; use of omega-3 in the past few months; Having obvious bleeding disorders or a history of using heparin and coumarin; The reluctance of patients participating in the study; use of other drugs such as statins; history of consumption or abuse of alcohol or drugs within 6 months from baseline.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Height. Timepoint: baseline and week 8. Method of measurement: meter.;Weight. Timepoint: baseline and week 8. Method of measurement: scale.;Abdominal circumference. Timepoint: baseline and week 8. Method of measurement: meter.;BMI. Timepoint: baseline and week 8. Method of measurement: kg/m2.;Triglyceride levels. Timepoint: baseline and week 8. Method of measurement: blood test.;Cholesterol. Timepoint: baseline and week 8. Method of measurement: blood test.;LDL. Timepoint: baseline and week 8. Method of measurement: blood test.;HDL. Timepoint: baseline and week 8. Method of measurement: blood test.;CRP. Timepoint: baseline and week 8. Method of measurement: blood test.;Inflammatory Mediators. Timepoint: baseline and week 8. Method of measurement: blood test.;CBC. Timepoint: baseline and week 8. Method of measurement: blood test.
- Secondary Outcome Measures
Name Time Method