Perioperative Pulmonary Recruitment and Postoperative Monitoring of Integrated Pulmonary Index in Off-pump Coronary Bypass Grafting

Northern State Medical University1 site in 1 country40 target enrollmentAugust 2015

ConditionsMechanical Ventilation Complication Postoperative Pulmonary Atelectasis

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Mechanical Ventilation Complication
Sponsor: Northern State Medical University
Enrollment: 40
Locations: 1
Primary Endpoint: Duration of postoperative mechanical ventilation
Status: Completed
Last Updated: 10 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

This study evaluates the influence of alveolar recruitment maneuver, protocolized liberation from respiratory support and monitoring of Integrated Pulmonary Index on the duration of the mechanical ventilation and the number of pulmonary complications in the early postoperative period after cardiac surgery.

Detailed Description

The outcome of elective off-pump coronary artery bypass grafting (OPCAB) can be significantly compromised due to early postoperative pulmonary complications. The risk of pulmonary complications including acute respiratory distress syndrome (ARDS), atelectases, and early ventilator-associated pneumonia remains inappropriate. Therefore, the maneuvers improving pulmonary aeration and the early restoration of spontaneous breathing activity can be of clinical value. Protocol-driven liberation from mechanical ventilation (CMV) can decrease the duration of CMV as well as the number of pulmonary complications. INTELLiVENT-Assisted spontaneous ventilation (INTELLiVENT-ASV) is a new approach, that may be as effective as conventional protocol-driven liberation from CMV. In parallel, the thorough postoperative monitoring of pulmonary function during both postoperative mechanical ventilation and spontaneous breathing is also of a great value. One of the novel approaches to respiratory monitoring is Integrated Pulmonary Index (IPI). The Integrated Pulmonary Index merges four vital parameters including end-tidal carbon dioxide (EtCO2), respiratory rate, pulse rate, and oxygen saturation (SpO2) measured by capnography and pulse oximetry into a single index value utilizing fuzzy logic model .

Registry

clinicaltrials.gov

Start Date

August 2015

End Date

February 2016

Last Updated

10 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Northern State Medical University

Responsible Party

Principal Investigator

Mikhail Y. Kirov

Professor, head of Anesthesiology dept.

Northern State Medical University

Eligibility Criteria

Inclusion Criteria

•Informed consent.
•Elective OPCAB.

Exclusion Criteria

•Participation in any other study.
•Morbid obesity (BWI \> 40).
•The risk of pneumothorax after alveolar recruitment due to pulmonary emphysema.
•Constant atrial fibrillation with pulse rate exceeding 100/min.
•Inability to breathe easily through the nostrils and thus to gain good quality EtCO2 readings while breathing spontaneously, due to chronic rhinitis.