Phase II Trial of Chemotherapy with Docetaxel plus Cisplatin for Patients with Recurrent or Metastatic Non-squamous Cell Carcinoma of Head and Neck - HN non-SCC_P2_DC

Medical Oncology / Hematology, Department of Medicine Kobe University Hospital and Graduate School of Medicine0 个研究点目标入组 23 人开始时间: 2012年9月1日最近更新: 2023年10月17日

适应症

试验速览

阶段: 2 期
状态: 已完成
发起方
入组人数: 23

研究概览入排标准研究者记录与标识符相似试验

研究概览

简要总结

DC regimen demonstrated promising efficacy in patients with R/M HN non-SCC. - ORR 45.5%, DCR 95.5% - mPFS 6.7 months, mOS 20.1 months No treatment-related deaths were observed. - FN 39% Prophylactic antibiotics seems to be effective. - 57 vs 11% (post-hoc analysis)

研究设计

研究类型: Interventional

入排标准

年龄范围: 20years-old 至 ot applicable（—）
性别: All

入选标准

未提供

排除标准

•1) Interval of at least 4 weeks from last surgery or radiotherapy, or interval of at least 2 weeks from last chemotherapy 2) Patients with pleural effusion, ascites and/or pericardial effusion requiring drainage 3) Active infection 4) Active concomitant malignancy 5) Symptomatic CNS metastases 6) Patients with uncontrollable complications 7) Pregnant, breast-feeding, or unwilling to use adequate contraception 8) HBsAg-positive 9) Other conditions inadequate for this research

研究者

发起方

Medical Oncology / Hematology, Department of Medicine Kobe University Hospital and Graduate School of Medicine

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