Exacerbation Prevention in chronic obstructive pulmonary disease (COPD) - using High Flow Therapy at home to reduce hospital readmission (EPIC-HFT UK)

Not Applicable

• Conditions: Chronic obstructive pulmonary disease (COPD); Respiratory

• Registration Number: ISRCTN89405844
• Lead Sponsor: Guy's and St Thomas' NHS Foundation Trust

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-05-23
• Last Update Posted: 18 July 2023
• Study Completion: 2027-03-19

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 502

Inclusion Criteria

1. Severe exacerbation of COPD*
2. Age 40-80 years
3. Diagnosis of COPD as defined by GOLD criteria
4. Smoking history of >10 pack years
5. Forced expiratory volume in 1 second (FEV1) <80% predicted
6. FEV1/FVC < 0.7**
*Severity defined by admission to hospital (acute admissions unit or hospital ward)
**post bronchodilator

Exclusion Criteria

1. Significant obesity (BMI >35kg/m²)
2. Clinically significant obstructive sleep apnoea syndrome requiring PAP therapy (see screening procedures for more detail)
3. Major non-COPD chronic co-morbidity that may significantly contribute to risk of readmission or death within 1 year
4. Home PAP or NIV therapy

Study & Design

• Study Type: Interventional
• Study Design: Not specified