Fructose Effect on Neuroinflammation and Feelings
- Conditions
- Gastro-Intestinal Disorder
- Interventions
- Other: Fructose respiratory test
- Registration Number
- NCT05371067
- Lead Sponsor
- University Hospital, Rouen
- Brief Summary
Fructose is increasingly present in our food. The increase in its consumption is associated with the increase in the prevalence of several pathologies such as metabolic syndrome or hepatic steatosis. The effect of fructose consumption on brain health has been poorly studied. Studies in animal models show that diets enriched in fructose promote the development of emotional behavior disorders. Fructose malabsorption is also associated with changes in the microbiota that could also impact brain health. However, no human study to date has associated fructose malabsorption with changes in the gut microbiota and effects on brain health.
The objective of this study is to study the emotional behavior of a population of healthy volunteers according to the presence or not of fructose malabsorption. Patients with fructose malabsorption are susceptible to gut dysbiosis without necessarily consuming high amounts of fructose.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Male
- Target Recruitment
- 55
- Healthy volunteers
- Aged 18 to 35
- Male sex
- BMI between 18.5 and 25
- Affiliation to a social security scheme
- Adult patient having read and understood the information letter and signed the consent form
- Presence of irritable bowel syndrome, celiac disease
- Presence of a psychiatric illness
- Presence of a neurodegenerative disease
- Presence of an eating disorder
- Presence of chronic disease, including inflammatory disease
- Presence of diabetes
- Presence of an acute infectious disease
- Presence of a surgical history of the digestive tract (excluding appendectomy)
- Taking long-term treatment
- Taking antibiotics within 6 months
- Taking probiotics within 3 months
- Typical diet low in lactose, FODMAP, gluten, vegetarian, vegan, vegan, chromonutrition .... in progress
- Smoker
- Person deprived of liberty by an administrative or judicial decision or person placed under judicial protection / under guardianship or guardianship
- Simultaneous participation in another interventional clinical trial
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Healthy volunteers Fructose respiratory test -
- Primary Outcome Measures
Name Time Method Evaluate the chronic effect of fructose on anxiety in healthy volunteers with fructose malabsorption compared to healthy volunteers without fructose malabsorption. At the inclusion visit (V1) Spielberger State Anxiety Questionnaire Score (STAI)
- Secondary Outcome Measures
Name Time Method Evaluate the fructose consumption in healthy volunteers with fructose malabsorption compared to healthy volunteers without fructose malabsorption. For 7 days before V2 Usual fructose consumption assessed by dietary log over 7 days
Evaluate the chronic effect of fructose on depression in healthy volunteers with fructose malabsorption compared to healthy volunteers without fructose malabsorption. At the inclusion visit (V1) HAD score
Evaluate the chronic effect of fructose on low-grade intestinal inflammation in healthy volunteers with fructose malabsorption compared to healthy volunteers without fructose malabsorption. up to 1 month Score STAI
Evaluate the chronic effect of fructose on microbiota's composition in healthy volunteers with fructose malabsorption compared to healthy volunteers without fructose malabsorption. up to 1 month Amplicon sequencing of the V3-V4 area (region) of bacterial 16S rRNA in volunteer's faeces
Trial Locations
- Locations (1)
CHU de ROUEN
🇫🇷Rouen, France