Deep Brain Stimulation for Patients With Parkinson's Disease.
- Conditions
- Parkinson Disease
- Interventions
- Device: Stimulation of the subthalamic nucleus
- Registration Number
- NCT03128567
- Lead Sponsor
- Institut National de la Sant茅 Et de la Recherche M茅dicale, France
- Brief Summary
Deep brain stimulation of the sub thalamic nucleus (STN-DBS) is an efficient treatment to improve motor and non motor signs of Parkinson's disease (PD). In people aged more 70 years, an increased rate of side effects such as post-operative cognitive decline and/or postural instability with falls has been suspected with less improvement in the quality of life. Here, Investigators aim further explore the effects of STN-DBS in 50 patients with PD people aged more 69 years in a randomized parallel controlled study.
- Detailed Description
The effects of combined bilateral deep brain stimulation of the subthalamic nucleus and medical treatment on the quality of life will be evaluated in 25 PD patients aged more 69 years in comparison to 25 PD patients aged more 69 years that only received medical drug treatment.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 10
- Parkinson's disease
- disease duration > 5 years
- levodopa related motor complications
- dopasensitivity > 50%
- signed informed written consent
- medical social insurance
- dementia
- contra-indication to neurosurgery
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Stimulation of the subthalamic nucleus Stimulation of the subthalamic nucleus 25 patients with Parkinson's disease
- Primary Outcome Measures
Name Time Method PDQ-39 Quality of life questionnary Quality of life one year after surgery PDQ-39 scale
- Secondary Outcome Measures
Name Time Method
Related Research Topics
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Trial Locations
- Locations (7)
Service d'EFSN, H么pital Pellegrin
馃嚝馃嚪Bordeaux, France
H么pital Roger Salengro - CHRU de Lille Service de Neurologie et Pathologie du Mouvement
馃嚝馃嚪Lille, France
H么pital Neurologique Pierre Wertheimer, Service de Neurologie
馃嚝馃嚪Lyon, France
D茅partement des maladies du Syst猫me Nerveux, H么pital Piti茅-Salp茅tri猫re
馃嚝馃嚪Paris, France
Service de Neurologie, P么le Neurosciences, CHU de Poitiers
馃嚝馃嚪Poitiers, France
CHU Charles Nicolle
馃嚝馃嚪Rouen, France
Centre d'Investigation Clinique - CIC 1436. CHU PURPAN. H么pital Pierre Paul Riquet
馃嚝馃嚪Toulouse, France