Effect of Progesterone Therapy on Traumatic Subarachinoid Haemorrhage on Clinical Outcome and Resistive Vasculer Indices of Middle Cerebral Artery Transcranial Doppler

Early Phase 1

• Conditions: Traumatic Brain Injury
• Interventions: Drug: Progesterone

• Registration Number: NCT04426487
• Lead Sponsor: Minia University

Brief Summary

Traumatic subarachinoid hemorrhage is associated with serious complications related to mortality . Delayed neuronal ischemia and rebleeding are most common and serious. Progesterone can delay both .

Detailed Description

Progesterone is an neurosteroid that can help integrity of blood brain barrier . Traumatic subarachinoid hemorrhage disrupts this blood brain barrier facilitating post traumatic vasospasm and neuronal ischemia. Transcranial doppler can detect cerebral vasoconstriction through resistive vasculer indices

Study Timeline

• Status Verified: 2020-06
• Study First Submitted: 2020-06-08
• Study First Submitted QC: 2020-06-08
• Last Update Submitted: 2020-06-08
• Study First Posted: 2020-06-11
• Last Update Posted: 2020-06-11
• Study Start: 2020-06-20
• Primary Completion: 2020-09-01
• Study Completion: 2020-10-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Traumatic subarachinoid hemorrhage

Read More

Exclusion Criteria

• History of malignency

  • History of cerebrovasculer stroke
  • Morbid obese

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control	Progesterone	Receiving conventional management for traumatic subarachinoid hemorrhage
progesterone group	Progesterone	Intramusculer progesterone therapy before and after craniotomy

Primary Outcome Measures

Name	Time	Method
Number of participants suffering neuronal infarction	2 months	Transcranial doppler

Trial Locations

Locations (1)

ElMinia University; 🇪🇬 Minya, Abohelal, Egypt