Utility of automated infrared pupillometry and Optic Nerve Sheath Diameter and as Initial Screening Tools in Severe Traumatic Brain Injury
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 84
- 试验地点
- 1
- 主要终点
- ICU stay duration
研究概览
简要总结
- Clinical need - Decisions to escalate beyond Seattle International Severe Traumatic Brain Injury
Consensus Conference SIBICC tier-0 carry major implications sedation hyperosmolar therapy ICP
monitoring and decompressive surgery. As a screening tool at admission can prioritize monitoring beds and
early interventions
- ORANGE study establishes NPi as a dynamic outcome predictor in acute brain injury—justifying NPi
as admission screen [4]
-
Ultrasound ONSD not only is a non-invasive and easy to do, quick procedure but also improves feasibility
-
To date no study has rigorously evaluated NPi + ONSD at admission to predict INCC (rather than ICP
alone or long-term outcome). Demonstrating that NPi less than 3 and or ONSD abnormal yields a low negative
likelihood ratio for requirement for intensive neurocritical care would provide a practical, non-invasive
rule-out bundle for early triage.
- Both AIP and ONSD can be completed within minutes of ICU arrival, prior to osmotherapy or deep
sedation, enabling early classification and potential protocolization across centres with varied
neuromonitoring capacity.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •1 Severe head trauma 2 Prehospital GCS less than 9 3 Intracranial lesion identified on initial CT head.
排除标准
- •1 Penetrating Head Injury 2 Bilateral ocular trauma or eyelid injury precluding pupillometry or ONSD 3 Prior enrolment in the study 4 Pre existing ocular disease significantly distorting ONSD or pupillary anatomy.
结局指标
主要结局
ICU stay duration
时间窗: 72 hours
In-hospital mortality
时间窗: 72 hours
Neurosurgical Intervention
时间窗: 72 hours
次要结局
未报告次要终点
研究者
Dr Anand Tiwari
Grant Medical Foundation Ruby Hall Clinic