Prospective Multi-center Study to Verify Neurological Prognostic Value of Amplitude-integrated Electroencephalogram in Cardiac Arrest Patients Treated With Therapeutic Hypothermia
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Heart Arrest
- Sponsor
- Seoul St. Mary's Hospital
- Enrollment
- 500
- Locations
- 4
- Primary Endpoint
- Comparison of time to normal trace to good neurological outcome evaluated by cerebral performance category (CPC) score 1 to 2
- Last Updated
- 8 years ago
Overview
Brief Summary
The investigators examine the prognostic value of continuous electroencephalography on frontal area of brain according to time by performing amplitude-integrated electroencephalography (aEEG) on cardiac arrest patients receiving therapeutic hypothermia.
Investigators
Kyu Nam Park
Professor
Seoul St. Mary's Hospital
Eligibility Criteria
Inclusion Criteria
- •age: 19 years and older
- •underwent TH
Exclusion Criteria
- •Died within 72 h after cardiac arrest
- •Spontaneous or traumatic brain injury
- •Known history of neurological diseases (such as epilepsy)
Outcomes
Primary Outcomes
Comparison of time to normal trace to good neurological outcome evaluated by cerebral performance category (CPC) score 1 to 2
Time Frame: at day 180
Time to normal trace is defined as time to regained normal trace on aEEG after return of spontaneous circulation. The normal trace is defined as continuous cortical activity on the raw EEG scan; in addition, the upper margin of the aEEG scan, referred to as the aEEG maximum, was \>10 uV, and the lower margin of the aEEG scan, referred to as the aEEG minimum, was \>5 uV.
Secondary Outcomes
- Comparison of time to normal trace to poor neurological outcome evaluated by CPC score 3 to 5(at day 180)
- Comparison of unfavorable aEEG patterns to poor neurological outcome evaluated by CPC score 3 to 5(at day 180)
- Comparison of diffusion weighted image (DWI) to poor neurological outcome evaluated by CPC score 3 to 5(at day 180)
- Comparison of the levels of serum neuron specific enolase (NSE) to poor neurological outcome evaluated by CPC score 3 to 5(at day 180)
- Comparison of convulsive movement and electrical status epilepticus (SE) to poor neurological outcome evaluated by CPC score 3 to 5(at day 180)