Effects of Lycium Barbarum Supplements on the Progression of Senile Cataract in Hong Kong Chinese Population
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 238
- 试验地点
- 2
- 主要终点
- Lens Opacity Classification System III (LOCSIII)
研究概览
简要总结
With the rapid growing aging population, age-related eye diseases including cataract are becoming more prevalent. The demand for cataract surgery and post-surgical care posed enormous financial burdens to the government.
Lycium barbarum contains lutein and zeaxanthin which can filter the phototoxic blue light and neutralize the reactive oxygen species, thus provide a protective effect against cataract formation.
This study aims to determine the effects of Lycium barbarum Supplements on the progression of senile cataract in Hong Kong Chinese elderly.
详细描述
Please note that a manuscript for this study is being prepared. Detailed description will be provided after we come up with the final draft.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 60 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Unlikely to have cataract surgery within 3 years
- •Presence of mild to moderate cataract in one or both eyes, graded by Lens Opacities Classification System III (LOCSIII).
- •logMAR acuity equivalent to Snellen acuity of 20/63 or better
- •no previous history and clinical signs of glaucoma by determining intraocular pressure using applanation Tonometry (no more than 22mmHg)
- •no ocular anomalies: amblyopia, binocular anomalies, ocular trauma
- •no history of eye surgery, laser treatment, iritis, retinal crystalline deposits, macular degeneration, or optic nerve diseases
- •no extended use of systemic or ocular corticosteroid drugs
- •no concurrent participation of other systemic or ocular drug intervention study
排除标准
- •diabetes mellitus
- •renal failure
- •fat malabsorption syndrome
- •intestinal surgery history
- •chronic diarrhea
- •alcoholism
- •use of anticoagulants
- •regular use of nutritional supplements such as multi-vitamin, mineral and other antioxidant supplements (including Omega-3)
结局指标
主要结局
Lens Opacity Classification System III (LOCSIII)
时间窗: 3 years
次要结局
- Visual Acuity(3 years)
研究者
Chea-su Kee
Associate Professor
The Hong Kong Polytechnic University