Effects of Lycium Barbarum Supplements on the Progression of Senile Cataract in Hong Kong Chinese Population
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 238
- Locations
- 1
- Primary Endpoint
- Lens Opacity Classification System III (LOCSIII)
Study Overview
Brief Summary
With the rapid growing aging population, age-related eye diseases including cataract are becoming more prevalent. The demand for cataract surgery and post-surgical care posed enormous financial burdens to the government.
Lycium barbarum contains lutein and zeaxanthin which can filter the phototoxic blue light and neutralize the reactive oxygen species, thus provide a protective effect against cataract formation.
This study aims to determine the effects of Lycium barbarum Supplements on the progression of senile cataract in Hong Kong Chinese elderly.
Detailed Description
Please note that a manuscript for this study is being prepared. Detailed description will be provided after we come up with the final draft.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Prevention
- Masking
- Double (Participant, Outcomes Assessor)
Eligibility Criteria
- Ages
- 60 Years to 75 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Unlikely to have cataract surgery within 3 years
- •Presence of mild to moderate cataract in one or both eyes, graded by Lens Opacities Classification System III (LOCSIII).
- •logMAR acuity equivalent to Snellen acuity of 20/63 or better
- •no previous history and clinical signs of glaucoma by determining intraocular pressure using applanation Tonometry (no more than 22mmHg)
- •no ocular anomalies: amblyopia, binocular anomalies, ocular trauma
- •no history of eye surgery, laser treatment, iritis, retinal crystalline deposits, macular degeneration, or optic nerve diseases
- •no extended use of systemic or ocular corticosteroid drugs
- •no concurrent participation of other systemic or ocular drug intervention study
Exclusion Criteria
- •diabetes mellitus
- •renal failure
- •fat malabsorption syndrome
- •intestinal surgery history
- •chronic diarrhea
- •alcoholism
- •use of anticoagulants
- •regular use of nutritional supplements such as multi-vitamin, mineral and other antioxidant supplements (including Omega-3)
Arms & Interventions
Placebo
Starch
Intervention: Starch (Dietary Supplement)
Lycium Barbarum
Lycium Barbarum supplement
Intervention: Lycium Barbarum (Dietary Supplement)
Outcomes
Primary Outcomes
Lens Opacity Classification System III (LOCSIII)
Time Frame: 3 years
Secondary Outcomes
- Visual Acuity(3 years)
Investigators
Chea-su Kee
Associate Professor
The Hong Kong Polytechnic University