Retinal blood vessels in sleep apnea patients

Not Applicable

• Conditions: Obstructive Sleep Apnea; Eye - Diseases / disorders of the eye; Respiratory - Sleep apnoea

• Registration Number: ACTRN12614000475640
• Lead Sponsor: Macquarie University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-05-07
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

1.OSA patients undergoing overnight diagnostic polysomnography will be included
2.Gender: M/F
3.Age range: 18+
4.Clear ocular media with visual acuity >= 6/12.
5. Not on previous ocular study trial.

Exclusion Criteria

1.Women lactating, pregnant or of childbearing potential who are not willing to avoid becoming pregnant during the study.
2.Participants with a history of ocular disease(s) that are likely to interfere with the metabolism or excretion of test medications.
3.Participants with a history of a psychological illness or other conditions which may interfere with their ability to understand the study requirements.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Increased pulsatility index of retinal vessels in OSA patients. This will be assessed using post data capture analysis on retinal videos recorded from each individual. The pulse amplitude of both retinal artery and veins will be measured using custom algorithms in OSA and controls. [cross-sectional study, assessed at baseline only. We aim to recruit the target number of participants within 3 years. ]

Secondary Outcome Measures

Name	Time	Method
eed of ocular screening for OSA patients. If significant results are obtained, using methodology described in the primary outcome a screening tool may be developed to screen the eyes in OSA patients for early diagnosis[3 years]