Biomarkers of Inflammation and Endothelial Dysfunction in Patients With Myocardial Infarction With Non-obstructive Coronary Arteries
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- Levels of endhotelial disfunction biomarkers
研究概览
简要总结
Around 10% of patients with myocardial infarction (MI) present with nonobstructive coronary arteries (MINOCA) which pathophysiology is often uncertain. The aim of the study is to evaluate inflammation and endothelial dysfunction biomarkers in MINOCA patients during both acute and stable phases, comparing them with those with MI and obstructive coronary arteries (MICAD).
详细描述
Prospective observational study in patients with Myocardial Infarction (MI) divided into two groups: MI with obstructive coronary arteries (MICAD) and MI with non-obstructive coronary arteries (MINOCA). Levels of interleukin-6, tumor necrosis factor-alpha, high-sensitivity C- reactive protein, and asymmetric dimethylarginine will be determined at three time points: within the 24 hours from the onset of pain, discharge, and two months after MI. The association of biomarkers, normalized by peak troponin value, with the risk of MINOCA will be evaluated using logistic regression.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients admitted with Myocardial Infarction and undergo a coronariography
- •Patients must sign informed consent.
排除标准
- •Patients who don´t sign informed consent
结局指标
主要结局
Levels of endhotelial disfunction biomarkers
时间窗: At three time points: within the 24 hours from the onset of pain, on the 5th day of admission, and two months after MI.
Levels of asymmetric dimethylarginine will be determined
Levels of high-sensitivity C-reactive protein (mg/L)
时间窗: t three time points: within the 24 hours from the onset of pain, on the 5th day of admission, and two months after MI.
Levels of high-sensitivity C-reactive protein (mg/L) will be determined.
Levels of interleukin-6 (pg/ml) and tumor necrosis factor-alpha (pg/ml)
时间窗: At three time points: within the 24 hours from the onset of pain, on the 5th day of admission, and two months after MI.
Levels of interleukin-6 (pg/ml) and tumor necrosis factor-alpha (pg/ml) will be determined.
次要结局
未报告次要终点
研究者
maria jesus espinosa pascual
Cardiologist
Hospital Universitario Getafe