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Clinical Trials/NCT05003674
NCT05003674
Completed
N/A

A Feasibility, Prospective, Multi-centre, Repeated-measures Study Evaluating the Performance of Focused Multipolar Stimulation in Adult Cochlear Implant Recipients

Cochlear4 sites in 1 country19 target enrollmentNovember 28, 2022

Overview

Phase
N/A
Intervention
Not specified
Conditions
Hearing Impairment
Sponsor
Cochlear
Enrollment
19
Locations
4
Primary Endpoint
Mean difference between stimulation modes for sentence perception in background noise (dB) (AuSTIN)
Status
Completed
Last Updated
last year

Overview

Brief Summary

This feasibility study is designed to explore several facets of hearing performance that may show improvements for alternative modes of stimulation compared to Monopolar (MP) stimulation within a group of adult cochlear-implant recipients. Measures of speech recognition, music appreciation, listening effort, quality of life, and real-world assessments will be gathered to determine the most promising benefits for further examination.

Detailed Description

Alternative modes of stimulation will be investigated that may improve spectral resolution through reduced cochlear spread of excitation and in turn provide enhanced speech perception and real-world clinical benefits over MP stimulation. The purpose of this feasibility study is to explore several facets of hearing performance that may show improvements with these alternative modes of stimulation compared to MP stimulation within a group of adult cochlear-implant recipients. Measures of speech recognition, music appreciation, listening effort, quality of life, and real-world assessments will be gathered to determine the most promising benefits for further examination. Individual neural, psychophysical, cognitive, and electrode placement data will also be obtained to inform questions related to across-subject variability, and practical aspects of power consumption and device fitting will be evaluated.

Registry
clinicaltrials.gov
Start Date
November 28, 2022
End Date
April 7, 2025
Last Updated
last year
Study Type
Interventional
Study Design
Crossover
Sex
All

Investigators

Sponsor
Cochlear
Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Adults 18 years of age or older.
  • Candidate for unilateral cochlear implant with Slim Modiolar electrode array as determined by the implanting centre.
  • English spoken as a primary language.
  • Willingness to comply with all investigational requirements.
  • Willing and able to provide written informed consent.

Exclusion Criteria

  • Previous or existing cochlear-implant recipient.
  • Evidence of severe or greater sensorineural hearing loss prior to five years of age.
  • Open-set pre-operative word score \> 70% in the contralateral ear.
  • Duration of severe to profound hearing loss \> 20 years in the ear to be implanted.
  • Adults with functional acoustic hearing in the ear to be implanted who desire to use an acoustic component in the implanted ear.
  • Ossification or other cochlear anomaly that might prevent complete insertion of the electrode array.
  • Hearing loss of neural or central origin.
  • Medical or psychological conditions that would contraindicate undergoing surgery.
  • Women who are pregnant.
  • Additional handicaps that would prevent or restrict participation in the audiological evaluations.

Outcomes

Primary Outcomes

Mean difference between stimulation modes for sentence perception in background noise (dB) (AuSTIN)

Time Frame: 7 months

Study Sites (4)

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