Streamlining Care Delivery in the Paediatric Emergency Department Using Rapid Point-of-care Diagnostics for Group a Streptococcus: a Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 392
- 试验地点
- 2
- 主要终点
- Appropriate antibiotic treatment
研究概览
简要总结
Randomized trial evaluating effectiveness of rapid point-of-care molecular GAS diagnostics as compared to standard culture-based techniques for the management of children aged 3-18 years of age presenting with sore throat to McMaster Children's Hospital Emergency Department.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 3 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •all those presenting who have a throat swab ordered for GAS testing
排除标准
- •those who took antibiotics effective against GAS within 72 h of ED presentation
结局指标
主要结局
Appropriate antibiotic treatment
时间窗: 3-5 days post-enrolment
All participants will be contacted by phone to ascertain whether they took antibiotics for the treatment of streptococcal pharyngitis. 'Appropriate antibiotic treatment' is a dichotomous measure. If the participant's throat swab was positive for GAS and they took antibiotics, or if their throat swab was negative for GAS and they did NOT take antibiotics, antibiotic treatment will be deemed 'appropriate.' All other scenarios will be deemed not 'appropriate.'
次要结局
- Caregiver satisfaction with testing(3-5 days post-enrolment)
- Number of days of missed work (caregiver)(3-5 and 7-10 days post-enrolment)
- Proportion of point-of-care GAS tests that are uninterpretable(at enrolment)
- Number of days of missed school/daycare(3-5 and 7-10 days post-enrolment)
- ED MD satisfaction with testing(At enrolment)
- Time required to utilize point-of-care testing(at enrolment)
- Number of healthcare visits for pharyngitis or sinopulmonary infections(7 days post-enrolment)
- Number of household contacts subsequently diagnosed with GAS pharyngitis(7-10 days post-enrolment)
- Time to resolution of symptoms(3-5 and 7-10 days post-enrolment)