Comparison of G-CSF & Antibiotics Versus Antibiotics Alone in Resolution of Febrile Neutropenia
Phase 4
Not yet recruiting
- Conditions
- Febrile NeutropeniaFebrile Neutropenia, Rule of Clinical Decision, ChemotherapyFebrile Neutropenia, Drug-InducedG-CSFAntibiotic Therapy
- Interventions
- Drug: Antibiotics only
- Registration Number
- NCT06988826
- Lead Sponsor
- King Edward Medical University
- Brief Summary
This study aim to find the best option for children having cancer who develop low immunity state due to chemotherapy
- Detailed Description
Children having a cancer diagnosis and treated with chemotherapy often develop neutropenia. This creates an immunocompromised state which can result in infections manifested by fever. This study compares two treatment options to find out the best treatment for these patients.
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 150
Inclusion Criteria
- Age 1-16 years
- any Gender
- Febrile neutropenia
- diagnosed case of solid or hematological malignancy
- taking chemotherapy
Exclusion Criteria
- Non-neutropenic fever
- already received G-CSF or antibiotics before presenting to hospital
- any other cause of neutropenia
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Group 1 G-CSF G-CSF plus antibiotic therapy Group 2 Antibiotics only Antibiotic Therapy
- Primary Outcome Measures
Name Time Method Resolution of FN 2 weeks Duration of resolution of febrile neutropenia (in days)
- Secondary Outcome Measures
Name Time Method Afebrile 2 weeks Duration of resolution of fever (in days)
Length of hospital stay 2 weeks Length of hospital stay (in days)