MedPath

Prostate Radiation Therapy or Short-Term Androgen Deprivation Therapy and Pelvic Lymph Node Radiation Therapy With or Without Prostate Radiation Therapy in Treating Patients With a Rising Prostate Specific Antigen (PSA) After Surgery for Prostate Cancer

Phase 3
Active, not recruiting
Conditions
Prostate Cancer
Interventions
Radiation: PBRT
Drug: AA
Radiation: PLNRT
Drug: LHRH agonist
Registration Number
NCT00567580
Lead Sponsor
Radiation Therapy Oncology Group
Brief Summary

RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Androgens can cause the growth of prostate cancer cells. Antihormone therapy, such as flutamide, bicalutamide, and luteinizing hormone-releasing hormone agonist, may lessen the amount of androgens made by the body. It is not yet known which regimen of radiation therapy with or without androgen-deprivation therapy is more effective for prostate cancer.

PURPOSE: This randomized phase III trial is studying prostate radiation therapy to see how well it works compared with short-term androgen deprivation therapy given together with pelvic lymph node radiation therapy with or without prostate radiation therapy in treating patients with a rising PSA after surgery for prostate cancer.

Detailed Description

OBJECTIVES:

Primary

* To determine whether the addition of short-term androgen deprivation (STAD) to prostate bed radiotherapy (PBRT) improves freedom from progression (FFP) (i.e., maintenance of a prostate-specific antigen \[PSA\] less than the nadir+2 ng/mL, absence of clinical failure, and absence of death from any cause) for 5 years, over that of PBRT alone in men treated with salvage radiotherapy after radical prostatectomy.

* To determine whether STAD, pelvic lymph node radiotherapy (PLNRT), and PBRT improves FFP over that of STAD+PBRT and PBRT alone in men treated with salvage radiotherapy after radical prostatectomy.

Secondary

* To compare secondary biochemical failure, the development of hormone-refractory disease , distant metastasis, cause-specific mortality, and overall mortality at five years.

* To compare acute and late morbidity based on Common Toxicity Criteria for Adverse Effects (CTCAE), v. 3.0.

* To measure the expression of cell kinetic, apoptotic pathway, and angiogenesis-related genes in archival diagnostic tissue to better define the risk of FFP, distant failure, cause-specific mortality, and overall mortality after salvage radiotherapy for prostate cancer, independently of conventional clinical parameters now used.

* To quantify blood product-based proteomic and genomic (single nucleotide polymorphisms) patterns and urine-based genomic patterns before and at different times after treatment to better define the risk of FFP, distant failure, cause-specific mortality, and overall mortality after salvage radiotherapy for prostate cancer, independently of conventional clinical parameters now used.

* To assess the degree, duration, and significant differences of disease-specific health-related quality of life (HRQOL) decrements among treatment arms.

* To assess whether mood is improved and depression is decreased with the more aggressive therapy if it improves FFP.

* To collect paraffin-embedded tissue blocks, serum, plasma, urine, and buffy coat cells for future translational research analyses.

Tertiary

* To assess whether an incremental gain in FFP and survival with more aggressive therapy outweighs decrements in the primary generic domains of HRQOL (i.e., mobility, self care, usual activities, pain/discomfort, and anxiety/depression).

* To evaluate the cost-utility of the treatment arm demonstrating the most significant benefit (in terms of the primary outcome) in comparison with other widely accepted cancer and non-cancer therapies.

* To assess associations between serum levels of beta-amyloid and measures of cognition and mood and depression.

* An exploratory aim is to assess the relationship(s) between the American Urological Association Symptom Index (AUA SI) and urinary morbidity using the CTCAE v. 3.0 grading system.

OUTLINE: Patients are stratified according to seminal vesicle involvement (yes vs no), prostatectomy Gleason score (≤ 7 vs 8-9), pre-radiotherapy PSA (≥ 0.1 and ≤ 1.0 ng/mL vs \> 1.0 and \< 2.0 ng/mL), and pathology stage (pT2 and margin negative vs all others). Patients are randomized to 1 of 3 treatment arms.

Follow-up occurs 3, 6, and 12 months after the completion of radiation therapy, then every 6 months for 6 years, and then annually thereafter.

Recruitment & Eligibility

Status
ACTIVE_NOT_RECRUITING
Sex
Male
Target Recruitment
1792
Inclusion Criteria
  1. Adenocarcinoma of the prostate treated primarily with radical prostatectomy, pathologically proven to be lymph node negative by pelvic lymphadenectomy (N0) or lymph node status pathologically unknown (undissected pelvic lymph nodes [Nx]), i.e. lymph node dissection is not required;

    • Any type of radical prostatectomy will be permitted, including retropubic, perineal, laparoscopic or robotically assisted. There is no time limit for the date of radical prostatectomy.

  2. A post-radical prostatectomy entry prostate-specific antigen (PSA) of ≥ 0.1 and < 2.0 ng/mL at least 6 weeks (45 days) after prostatectomy and within 30 days of registration;

  3. One of the following pathologic classifications:

    • T3N0/Nx disease with or without a positive prostatectomy surgical margin; or
    • T2N0/Nx disease with or without a positive prostatectomy surgical margin;
  4. Prostatectomy Gleason score of 9 or less;

  5. Zubrod Performance Status of 0-1;

  6. Age ≥ 18;

  7. No distant metastases, based upon the following minimum diagnostic workup:

    • History/physical examination (including digital rectal exam) within 8 weeks (60 days) prior to registration;
    • A computerized tomography (CT) scan of the pelvis (with contrast if renal function is acceptable; a noncontrast CT is permitted if the patient is not a candidate for contrast) or magnetic resonance imaging (MRI) of the pelvis within 120 days prior to registration;
    • Bone scan within 120 days prior to registration; if the bone scan is suspicious, a plain x-ray and/or MRI must be obtained to rule out metastasis.
  8. Adequate bone marrow function, within 90 days prior to registration, defined as follows:

    • Platelets ≥ 100,000 cells/mm^3 based upon compete blood count (CBC);
    • Hemoglobin ≥ 10.0 g/dl based upon CBC (Note: The use of transfusion or other intervention to achieve Hgb ≥ 10.0 g/dl is recommended).
  9. Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) < 2 x the upper limit of normal within 90 days prior to registration;

  10. Serum total testosterone must be ≥ 40% of the lower limit of normal (LLN) of the assay used (testosterone ÷ LLN must be ≥ 0.40) within 90 days prior to registration (Note: Patients who have had a unilateral orchiectomy are eligible as long as this requirement is met);

  11. Patients must sign a study-specific informed consent prior to study entry.

Exclusion Criteria
  1. A palpable prostatic fossa abnormality/mass suggestive of recurrence, unless shown by biopsy under ultrasound guidance not to contain cancer;

  2. N1 patients are ineligible, as are those with pelvic lymph node enlargement ≥ 1.5 cm in greatest dimension by CT scan or MRI of the pelvis, unless the enlarged lymph node is sampled and is negative;

  3. Androgen deprivation therapy started prior to prostatectomy for > 6 months (180 days) duration. Note: The use of finasteride or dutasteride (±tamsulosin) for longer periods prior to prostatectomy is acceptable;

  4. Androgen deprivation therapy started after prostatectomy and prior to registration (Note: The use of finasteride or dutasteride (±tamsulosin) after prostatectomy is not acceptable - must be stopped within 3 months after prostatectomy. Androgen deprivation therapy must be stopped within 3 months after prostatectomy);

  5. Neoadjuvant chemotherapy before or after prostatectomy;

  6. Prior chemotherapy for any other disease site if given within 5 years prior to registration;

  7. Prior cryosurgery or brachytherapy of the prostate; prostatectomy should be the primary treatment and not a salvage procedure;

  8. Prior pelvic radiotherapy;

  9. Prior invasive malignancy (except non-melanomatous skin cancer) or superficial bladder cancer unless disease free for a minimum of 5 years [for example, carcinoma in situ of the oral cavity is permissible];

  10. Severe, active co-morbidity, defined as follows:

    • History of inflammatory bowel disease;
    • History of hepatitis B or C; Blood tests are not required to determine if the patient has had hepatitis B or C, unless the patient reports a history of hepatitis.
    • Unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months;
    • Transmural myocardial infarction within the last 6 months;
    • Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration;
    • Chronic Obstructive Pulmonary Disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of registration;
    • Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects; AST or ALT are required; note, however, that laboratory tests for coagulation parameters are not required for entry into this protocol.
    • Acquired Immune Deficiency Syndrome (AIDS) based upon current Centers for Disease Control and Prevention (CDC) definition; Note, however, that human immunodeficiency viruses (HIV) testing is not required for entry into this protocol. The need to exclude patients with acquired immunodeficiency syndrome (AIDS) from this protocol is necessary because the treatments involved in this protocol may result in increased toxicity and immunosuppression.
  11. Prior allergic reaction to the study drug(s) involved in this protocol.

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
PBRT AlonePBRTProstate bed radiotherapy (PBRT) begins within 6 weeks (+/- 2 weeks) after registration.
PBRT + STADPBRTProstate bed radiotherapy (PBRT) and short term androgen deprivation therapy (STAD) consisting of antiandrogen (AA) and luteinizing hormone-releasing hormone (LHRH) agonist therapy begins within 6 weeks (+/- 2 weeks) after registration. STAD starts first, 2 months (+/- 2 weeks) before radiotherapy (RT), and lasts for 4-6 months. LHRH can last 4-6 months. AA starts at the same time as LHRH (or up to 2 weeks prior ), lasts approximately 4 months, and should end on the last day of RT (+/- 2 weeks).
PBRT + STADAAProstate bed radiotherapy (PBRT) and short term androgen deprivation therapy (STAD) consisting of antiandrogen (AA) and luteinizing hormone-releasing hormone (LHRH) agonist therapy begins within 6 weeks (+/- 2 weeks) after registration. STAD starts first, 2 months (+/- 2 weeks) before radiotherapy (RT), and lasts for 4-6 months. LHRH can last 4-6 months. AA starts at the same time as LHRH (or up to 2 weeks prior ), lasts approximately 4 months, and should end on the last day of RT (+/- 2 weeks).
PBRT + STADLHRH agonistProstate bed radiotherapy (PBRT) and short term androgen deprivation therapy (STAD) consisting of antiandrogen (AA) and luteinizing hormone-releasing hormone (LHRH) agonist therapy begins within 6 weeks (+/- 2 weeks) after registration. STAD starts first, 2 months (+/- 2 weeks) before radiotherapy (RT), and lasts for 4-6 months. LHRH can last 4-6 months. AA starts at the same time as LHRH (or up to 2 weeks prior ), lasts approximately 4 months, and should end on the last day of RT (+/- 2 weeks).
PLNRT + PBRT + STADTPBRTPelvic lymph node radiotherapy (PLNRT), prostate bed radiotherapy (PBRT), and short term androgen deprivation therapy (STAD) consisting of antiandrogen (AA) and luteinizing hormone-releasing hormone (LHRH) agonist therapy begins within 6 weeks (+/- 2 weeks) after registration. STAD starts first, 2 months (+/- 2 weeks) before RT, and lasts for 4-6 months. LHRH can last 4-6 months. AA starts at the same time as LHRH (or up to 2 weeks prior ), lasts approximately 4 months, and should end on the last day of RT (+/- 2 weeks).
PLNRT + PBRT + STADTPLNRTPelvic lymph node radiotherapy (PLNRT), prostate bed radiotherapy (PBRT), and short term androgen deprivation therapy (STAD) consisting of antiandrogen (AA) and luteinizing hormone-releasing hormone (LHRH) agonist therapy begins within 6 weeks (+/- 2 weeks) after registration. STAD starts first, 2 months (+/- 2 weeks) before RT, and lasts for 4-6 months. LHRH can last 4-6 months. AA starts at the same time as LHRH (or up to 2 weeks prior ), lasts approximately 4 months, and should end on the last day of RT (+/- 2 weeks).
PLNRT + PBRT + STADTAAPelvic lymph node radiotherapy (PLNRT), prostate bed radiotherapy (PBRT), and short term androgen deprivation therapy (STAD) consisting of antiandrogen (AA) and luteinizing hormone-releasing hormone (LHRH) agonist therapy begins within 6 weeks (+/- 2 weeks) after registration. STAD starts first, 2 months (+/- 2 weeks) before RT, and lasts for 4-6 months. LHRH can last 4-6 months. AA starts at the same time as LHRH (or up to 2 weeks prior ), lasts approximately 4 months, and should end on the last day of RT (+/- 2 weeks).
PLNRT + PBRT + STADTLHRH agonistPelvic lymph node radiotherapy (PLNRT), prostate bed radiotherapy (PBRT), and short term androgen deprivation therapy (STAD) consisting of antiandrogen (AA) and luteinizing hormone-releasing hormone (LHRH) agonist therapy begins within 6 weeks (+/- 2 weeks) after registration. STAD starts first, 2 months (+/- 2 weeks) before RT, and lasts for 4-6 months. LHRH can last 4-6 months. AA starts at the same time as LHRH (or up to 2 weeks prior ), lasts approximately 4 months, and should end on the last day of RT (+/- 2 weeks).
Primary Outcome Measures
NameTimeMethod
Percentage of Participants Free From Progression (FFP) at 5 YearsFrom randomization to five years.

Progression is defined as the first occurrence of the following events: biochemical failure by the Phoenix definition (prostate-specific antigen \[PSA\] ≥ 2 ng/ml over the nadir PSA), clinical failure (local, regional or distant), or death from any cause. The initiation of second salvage therapy before progression was a protocol violation and resulted in censoring. Progression time is defined as time from randomization to the date of progression, second salvage therapy (censored), or last known follow-up (censored). Freedom from progression rates are estimated using the Kaplan-Meier method. The study was designed for the final analysis to occur after all participants had been on study for at least 5 years, but results were reported early. See Limitations and Caveats section.

Secondary Outcome Measures
NameTimeMethod
Assessment and Comparison of Quality Adjusted Life Year (QALY) and Quality Adjusted FFP Year (QAFFPY)From the 6th week of radiation therapy to 5 years post radiation therapy.
Evaluation and Comparison of the Cost-utility Using EuroQoL - 5 Dimensions (EQ-5D)From the 6th week of radiation therapy to 5 years post radiation therapy.
Prognostic Value of Genomic and Proteomic Markers for the Primary and Secondary Clinical EndpointsDate of randomization to timepoint of the respective primary or secondary endpoint.
Percentage of Participants With Secondary Biochemical Failure (Alternative Biochemical Failure)From randomization to last follow-up. Maximum follow-up at time of analysis was 10.5 years.

Secondary biochemical (failure) is defined as either of two occurrences: 1. For detectable post-baseline PSA values (≥ 0.1), the first occurrence of a PSA value that is both ≥ 0.4 and a second rise above nadir; 2.The start of second salvage therapy. Failure time is defined as time from randomization to the date of failure, death (competing risk), or last known follow-up (censored). Failure rates for data summary are estimated using the cumulative incidence method, with 5-year rates provided here. Pairwise comparisons of the distributions of failure times, reported in the statistical analysis section, use cause-specific hazard rates for which deaths are censored. The study was designed for the final analysis to occur after all participants had been on study for at least 5 years, but results were reported early. See Limitations and Caveats section.

Percentage of Participants Free From Hormone-refractory Disease (Castrate-resistant Disease)From randomization to last follow-up. Maximum follow-up at time of analysis was 10.5 years.

Hormone-refractory disease (failure) is defined as three rises in PSA after the start of second salvage androgen deprivation therapy. Failure time is defined as time from randomization to the date of failure, death (competing risk), or last known follow-up (censored). Failure rates for data summary are estimated using the cumulative incidence method, with 5-year rates provided here. Pairwise comparisons of the distributions of failure times, reported in the statistical analysis section, use cause-specific hazard rates for which deaths are censored. The study was designed for the final analysis to occur after all participants had been on study for at least 5 years, but the data monitoring committee decided to release results after the third interim analysis.

Percentage of Participants With Local FailureFrom randomization to last follow-up. Maximum follow-up at time of analysis was 10.5 years.

Local failure is defined as first occurrence of local clinical progression. Failure time is defined as time from randomization to the date of failure, death (competing risk), or last known follow-up (censored). Failure rates for data summary are estimated using the cumulative incidence method, with 5-year rates provided here. Pairwise comparisons of the distributions of failure times, reported in the statistical analysis section, use cause-specific hazard rates for which deaths are censored. The study was designed for the final analysis to occur after all participants had been on study for at least 5 years, but the data monitoring committee decided to release results after the third interim analysis.

Percentage of Participants With Distant MetastasisFrom randomization to last follow-up. Maximum follow-up at time of analysis was 10.5 years.

Distant metastasis (failure) is defined as the occurrence of distant metastasis determined by imaging. Failure time is defined as time from randomization to the date of failure, death (competing risk), or last known follow-up (censored). Failure rates for data summary are estimated using the cumulative incidence method, with 5-year rates provided here. Pairwise comparisons of the distributions of failure times, reported in the statistical analysis section, use cause-specific hazard rates for which deaths are censored. The study was designed for the final analysis to occur after all participants had been on study for at least 5 years, but the data monitoring committee decided to release results after the third interim analysis.

Percentage of Participants Who Died Due to Prostate Cancer (Cause-specific Mortality)From randomization to last follow-up. Maximum follow-up at time of analysis was 10.5 years.

Cause-specific mortality (failure) is defined as death due to prostate cancer or complications of protocol treatment (centrally reviewed), or death following disease progression (clinical or biochemical) in the absence of or after the initiation of any salvage therapy. \[Biochemical progression is indicated by any rise in PSA.\] Failure time is defined as time from randomization to the date of failure, death (competing risk), or last known follow-up (censored). Failure rates for data summary are estimated using the cumulative incidence method, with 5-year rates provided here. Pairwise comparisons of the distributions of failure times, reported in the statistical analysis section, use cause-specific hazard rates for which deaths are censored. The study was designed for the final analysis to occur after all participants had been on study for at least 5 years, but the data monitoring committee decided to release results after the third interim analysis.

Percentage of Participants Alive (Overall Mortality)From randomization to last follow-up. Maximum follow-up at time of analysis was 10.5 years.

Survival time is defined as time from randomization to the date of death from any cause or last known follow-up (censored). Survival rates are estimated by the Kaplan-Meier method. Pairwise comparisons of the overall distributions of failure times are reported in statistical analysis section, with five-year rates reported here. The study was designed for the final analysis to occur after all participants had been on study for at least 5 years, but the data monitoring committee decided to release results after the third interim analysis.

Percentage of Participants Experiencing Grade 2+ and 3+ Adverse Events ≤ 90 Days of the Completion of Radiotherapy (RT)From randomization to 90 days after completion of radiotherapy (approximately 7-8 weeks).

Common Terminology Criteria for Adverse Events (version 3.0) grades adverse event severity from 1=mild to 5=death. Summary data is provided in this outcome measure; see Adverse Events Module for specific adverse event data. Pairwise comparisons of Arm 2 vs Arm 1 and Arm 3 vs. Arm 2 are reported in the statistical analysis.

Comparison of Disease-specific Health Related Quality of Life (HRQOL) Change by the Expanded Prostate Cancer Index Composite (EPIC), Hopkins Verbal Learning Test Revised (HVLT-R), Trail Making Test A & B, and Controlled Oral Word Association Test (COWAT)From the 6th week of radiation therapy to 5 years post radiation therapy.
Percentage of Participants Experiencing Late Grade 2+ and 3+ Adverse Events > 90 Days From the Completion of Radiotherapy (RT)AE: from 91 days after completion of RT (approximately 7-8 weeks) to last follow-up. Vital status: from randomization to last follow-up. Maximum follow-up at time of analysis was 10.5 years.

Common Terminology Criteria for Adverse Events (version 3.0) grades adverse event severity from 1=mild to 5=death. Late adverse events (AE) are defined as occurring \> 90 days from the completion of RT. Failure time is defined as time from randomization to the date of first late grade 2 or grade 3 adverse event, death (competing risk), or last known follow-up (censored). Failure rates for data summary are estimated using the cumulative incidence method, with 5-year rates provided here. Pairwise comparisons of the distributions of failure times between Arm 2 and Arm 1 and between Arm 3 and Arm 2, reported in the statistical analysis section, use cause-specific hazard rates for which deaths are censored.

Assessment of Mood and Depression Change Using QOL Measured by the Hopkins Symptom Checklist (HSCL-25)From the 6th week of radiation therapy to 5 years post radiation therapy.
Assessment of the Relationship(s) Between the American Urological Association Symptom Index (AUA SI) and Urinary Morbidity (Adverse Event Terms: Urinary Frequency/Urgency) Using the CTCAE v. 3.0 Grading SystemFrom the 6th week of radiation therapy to 5 years post radiation therapy.

Trial Locations

Locations (460)

Grant Medical Center Cancer Care

🇺🇸

Columbus, Ohio, United States

Mount Carmel Health - West Hospital

🇺🇸

Columbus, Ohio, United States

Doctors Hospital at Ohio Health

🇺🇸

Columbus, Ohio, United States

UPMC Cancer Center at Magee-Womens Hospital

🇺🇸

Pittsburgh, Pennsylvania, United States

UPMC Cancer Center at UPMC Presbyterian

🇺🇸

Pittsburgh, Pennsylvania, United States

UPMC Cancer Center at UPMC Passavant

🇺🇸

Pittsburgh, Pennsylvania, United States

UPMC Cancer Center - Upper St. Clair

🇺🇸

Pittsburgh, Pennsylvania, United States

Mount Sinai Hospital Medical Center

🇺🇸

Chicago, Illinois, United States

Case Comprehensive Cancer Center

🇺🇸

Cleveland, Ohio, United States

Cleveland Clinic Cancer Center at Fairview Hospital

🇺🇸

Cleveland, Ohio, United States

Massachusetts General Hospital

🇺🇸

Boston, Massachusetts, United States

Dana-Farber/Brigham and Women's Cancer Center

🇺🇸

Boston, Massachusetts, United States

Boston University Cancer Research Center

🇺🇸

Boston, Massachusetts, United States

Baptist-South Miami Regional Cancer Program

🇺🇸

Miami, Florida, United States

UCSF Helen Diller Family Comprehensive Cancer Center

🇺🇸

San Francisco, California, United States

California Pacific Medical Center - California Campus

🇺🇸

San Francisco, California, United States

Cancer Care Centers of South Texas - Northeast

🇺🇸

San Antonio, Texas, United States

Huntsman Cancer Institute at University of Utah

🇺🇸

Salt Lake City, Utah, United States

Arizona Oncology Services Foundation

🇺🇸

Phoenix, Arizona, United States

Josephine Ford Cancer Center at Henry Ford Hospital

🇺🇸

Detroit, Michigan, United States

Oklahoma University Cancer Institute

🇺🇸

Oklahoma City, Oklahoma, United States

East Bay Radiation Oncology Center

🇺🇸

Castro Valley, California, United States

Mercy Cancer Center at Mercy San Juan Medical Center

🇺🇸

Carmichael, California, United States

Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital

🇺🇸

Fairbanks, Alaska, United States

Peninsula Medical Center

🇺🇸

Burlingame, California, United States

Enloe Cancer Center at Enloe Medical Center

🇺🇸

Chico, California, United States

Radiation Oncology Centers - Cameron Park

🇺🇸

Cameron Park, California, United States

Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center

🇺🇸

Los Angeles, California, United States

USC/Norris Comprehensive Cancer Center and Hospital

🇺🇸

Los Angeles, California, United States

Contra Costa Regional Medical Center

🇺🇸

Martinez, California, United States

El Camino Hospital Cancer Center

🇺🇸

Mountain View, California, United States

Providence Holy Cross Cancer Center

🇺🇸

Mission Hills, California, United States

Memorial Medical Center

🇺🇸

Modesto, California, United States

Solano Radiation Oncology Center

🇺🇸

Vacaville, California, United States

Bay Area Breast Surgeons, Incorporated

🇺🇸

Oakland, California, United States

North Colorado Medical Center

🇺🇸

Greeley, Colorado, United States

Larry G Strieff MD Medical Corporation

🇺🇸

Oakland, California, United States

Pacific Cancer Institute - Maui

🇺🇸

Wailuku, Hawaii, United States

Tom K Lee, Incorporated

🇺🇸

Oakland, California, United States

Saint Helena Hospital

🇺🇸

Saint Helena, California, United States

Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center

🇺🇸

Boise, Idaho, United States

Creticos Cancer Center at Advocate Illinois Masonic Medical Center

🇺🇸

Chicago, Illinois, United States

Middlesex Hospital Cancer Center

🇺🇸

Middletown, Connecticut, United States

Robert H. Lurie Comprehensive Cancer Center at Northwestern University

🇺🇸

Chicago, Illinois, United States

St. Mary - Corwin Regional Medical Center

🇺🇸

Pueblo, Colorado, United States

Swedish Medical Center

🇺🇸

Englewood, Colorado, United States

University of Chicago Cancer Research Center

🇺🇸

Chicago, Illinois, United States

Flagler Cancer Center

🇺🇸

Saint Augustine, Florida, United States

Integrated Community Oncology Network

🇺🇸

Jacksonville Beach, Florida, United States

Decatur Memorial Hospital Cancer Care Institute

🇺🇸

Decatur, Illinois, United States

Baptist Cancer Institute - Jacksonville

🇺🇸

Jacksonville, Florida, United States

Integrated Community Oncology Network - Orange Park

🇺🇸

Orange Park, Florida, United States

Northside Hospital Cancer Center

🇺🇸

Atlanta, Georgia, United States

Leonard C. Ferguson Cancer Center

🇺🇸

Freeport, Illinois, United States

Veterans Affairs Medical Center - Hines

🇺🇸

Hines, Illinois, United States

Cancer Institute at St. John's Hospital

🇺🇸

Springfield, Illinois, United States

Regional Cancer Center at Memorial Medical Center

🇺🇸

Springfield, Illinois, United States

Radiation Oncology Associates Southwest

🇺🇸

Fort Wayne, Indiana, United States

Parkview Regional Cancer Center at Parkview Health

🇺🇸

Fort Wayne, Indiana, United States

Center for Cancer Care at Goshen General Hospital

🇺🇸

Goshen, Indiana, United States

Howard Community Hospital

🇺🇸

Kokomo, Indiana, United States

Center for Cancer Therapy at LaPorte Hospital and Health Services

🇺🇸

La Porte, Indiana, United States

St. Luke's Regional Medical Center

🇺🇸

Sioux City, Iowa, United States

Memorial Hospital of South Bend

🇺🇸

South Bend, Indiana, United States

Cancer Center of Kansas, PA - Wichita

🇺🇸

Wichita, Kansas, United States

Mercy Medical Center - Sioux City

🇺🇸

Sioux City, Iowa, United States

Cancer Center of Kansas, PA - Dodge City

🇺🇸

Dodge City, Kansas, United States

Associates in Womens Health, PA - North Review

🇺🇸

Wichita, Kansas, United States

Genesys Hurley Cancer Institute

🇺🇸

Flint, Michigan, United States

Cancer Center of Kansas, PA - Medical Arts Tower

🇺🇸

Wichita, Kansas, United States

Wesley Medical Center

🇺🇸

Wichita, Kansas, United States

McLaren Cancer Institute

🇺🇸

Flint, Michigan, United States

Beth Israel Deaconess Medical Center

🇺🇸

Boston, Massachusetts, United States

CCOP - Wichita

🇺🇸

Wichita, Kansas, United States

Henry Ford Macomb Hospital

🇺🇸

Clinton Township, Michigan, United States

Cape Cod Hospital

🇺🇸

Hyannis, Massachusetts, United States

Hudner Oncology Center at Saint Anne's Hospital - Fall River

🇺🇸

Fall River, Massachusetts, United States

Greenebaum Cancer Center at University of Maryland Medical Center

🇺🇸

Baltimore, Maryland, United States

Via Christi Cancer Center at Via Christi Regional Medical Center

🇺🇸

Wichita, Kansas, United States

Oakwood Cancer Center at Oakwood Hospital and Medical Center

🇺🇸

Dearborn, Michigan, United States

Central Maryland Oncology Center

🇺🇸

Columbia, Maryland, United States

St. Agnes Hospital Cancer Center

🇺🇸

Baltimore, Maryland, United States

Lowell General Hospital

🇺🇸

Lowell, Massachusetts, United States

Hickman Cancer Center at Bixby Medical Center

🇺🇸

Adrian, Michigan, United States

Virginia Piper Cancer Institute at Abbott - Northwestern Hospital

🇺🇸

Minneapolis, Minnesota, United States

United Hospital

🇺🇸

Saint Paul, Minnesota, United States

St. Luke's Hospital Cancer Care Center

🇺🇸

Duluth, Minnesota, United States

Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis

🇺🇸

Saint Louis, Missouri, United States

CCOP - Metro-Minnesota

🇺🇸

Saint Louis Park, Minnesota, United States

Park Nicollet Cancer Center

🇺🇸

Saint Louis Park, Minnesota, United States

Regions Hospital Cancer Care Center

🇺🇸

Saint Paul, Minnesota, United States

Immanuel St. Joseph's

🇺🇸

Mankato, Minnesota, United States

Siteman Cancer Center at Barnes-Jewish St. Peters Hospital - St. Peters

🇺🇸

Saint Peters, Missouri, United States

Great Falls Clinic - Main Facility

🇺🇸

Great Falls, Montana, United States

Sands Cancer Center

🇺🇸

Canandaigua, New York, United States

Lipson Cancer and Blood Center at Rochester General Hospital

🇺🇸

Rochester, New York, United States

Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton

🇺🇸

Marlton, New Jersey, United States

New York Methodist Hospital

🇺🇸

Brooklyn, New York, United States

CCOP - Nevada Cancer Research Foundation

🇺🇸

Las Vegas, Nevada, United States

Valley Hospital - Ridgewood

🇺🇸

Ridgewood, New Jersey, United States

Somerset Medical Center

🇺🇸

Somerville, New Jersey, United States

Frederick R. and Betty M. Smith Cancer Treatment Center

🇺🇸

Sparta, New Jersey, United States

New York Oncology Hematology, PC at Albany Regional Cancer Care

🇺🇸

Albany, New York, United States

University of New Mexico Cancer Center - South

🇺🇸

Las Cruces, New Mexico, United States

Memorial Sloan-Kettering Cancer Center

🇺🇸

Commack, New York, United States

Memorial Sloan-Kettering Cancer Center at Phelps Memorial Hospital Center

🇺🇸

Sleepy Hollow, New York, United States

Moses Cone Regional Cancer Center at Wesley Long Community Hospital

🇺🇸

Greensboro, North Carolina, United States

CarolinaEast Cancer Care

🇺🇸

New Bern, North Carolina, United States

Annie Penn Cancer Center

🇺🇸

Reidsville, North Carolina, United States

Rex Cancer Center at Rex Hospital

🇺🇸

Raleigh, North Carolina, United States

Zimmer Cancer Center at New Hanover Regional Medical Center

🇺🇸

Wilmington, North Carolina, United States

Coastal Carolina Radiation Oncology Center

🇺🇸

Wilmington, North Carolina, United States

South Atlantic Radiation Oncology, LLC

🇺🇸

Supply, North Carolina, United States

Altru Cancer Center at Altru Hospital

🇺🇸

Grand Forks, North Dakota, United States

McDowell Cancer Center at Akron General Medical Center

🇺🇸

Akron, Ohio, United States

Barberton Citizens Hospital

🇺🇸

Barberton, Ohio, United States

Aultman Cancer Center at Aultman Hospital

🇺🇸

Canton, Ohio, United States

Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center

🇺🇸

Columbus, Ohio, United States

CCOP - Columbus

🇺🇸

Columbus, Ohio, United States

Cleveland Clinic Taussig Cancer Center

🇺🇸

Cleveland, Ohio, United States

North Coast Cancer Care, Incorporated

🇺🇸

Sandusky, Ohio, United States

Cleveland Clinic Foundation - Strongsville

🇺🇸

Strongsville, Ohio, United States

Mercy Hospital of Tiffin

🇺🇸

Tiffin, Ohio, United States

Medical University of Ohio Cancer Center

🇺🇸

Toledo, Ohio, United States

Providence Cancer Center at PMCC

🇺🇸

Medford, Oregon, United States

Legacy Mount Hood Medical Center

🇺🇸

Gresham, Oregon, United States

Legacy Meridian Park Hospital

🇺🇸

Tualatin, Oregon, United States

UPMC Cancer Center at the John P. Murtha Pavilion

🇺🇸

Johnstown, Pennsylvania, United States

Dubs Cancer Center at Rogue Valley Medical Center

🇺🇸

Medford, Oregon, United States

Salem Hospital Regional Cancer Care Services

🇺🇸

Salem, Oregon, United States

Bryn Mawr Hospital

🇺🇸

Bryn Mawr, Pennsylvania, United States

St. Luke's Cancer Network at St. Luke's Hospital

🇺🇸

Bethlehem, Pennsylvania, United States

Rosenfeld Cancer Center at Abington Memorial Hospital

🇺🇸

Abington, Pennsylvania, United States

UPMC Cancer Center - Arnold Palmer Pavilion

🇺🇸

Greensburg, Pennsylvania, United States

Allegheny Cancer Center at Allegheny General Hospital

🇺🇸

Pittsburgh, Pennsylvania, United States

UPMC - Shadyside

🇺🇸

Pittsburgh, Pennsylvania, United States

Alle-Kiski Medical Center

🇺🇸

Natrona Heights, Pennsylvania, United States

St. Mary Regional Cancer Center

🇺🇸

Langhorne, Pennsylvania, United States

UPMC - Moon

🇺🇸

Moon, Pennsylvania, United States

UPMC Cancer Center - Natrona Heights

🇺🇸

Natrona Heights, Pennsylvania, United States

Intercommunity Cancer Center

🇺🇸

Monroeville, Pennsylvania, United States

Kimmel Cancer Center at Thomas Jefferson University - Philadelphia

🇺🇸

Philadelphia, Pennsylvania, United States

Washington Hospital Cancer Center

🇺🇸

Washington, Pennsylvania, United States

UPMC Cancer Center at UPMC St. Margaret

🇺🇸

Pittsburgh, Pennsylvania, United States

Cancer Centers of the Carolinas - Seneca

🇺🇸

Seneca, South Carolina, United States

Cancer Centers of the Carolinas - Spartanburg

🇺🇸

Spartanburg, South Carolina, United States

CCOP - Main Line Health

🇺🇸

Wynnewood, Pennsylvania, United States

Cancer Centers of the Carolinas - Eastside

🇺🇸

Greenville, South Carolina, United States

Cancer Centers of the Carolinas - Faris Road

🇺🇸

Greenville, South Carolina, United States

CCOP - Greenville

🇺🇸

Greenville, South Carolina, United States

Cancer Centers of the Carolinas - Greer Medical Oncology

🇺🇸

Greer, South Carolina, United States

Cancer Centers of the Carolinas - Greer Radiation Oncology

🇺🇸

Greer, South Carolina, United States

Memorial Hermann Hospital - Memorial City

🇺🇸

Houston, Texas, United States

Texas Oncology, PA at Lake Vista Cancer Center

🇺🇸

Lewisville, Texas, United States

Val and Ann Browning Cancer Center at McKay-Dee Hospital Center

🇺🇸

Ogden, Utah, United States

West Tennessee Cancer Center at Jackson-Madison County General Hospital

🇺🇸

Jackson, Tennessee, United States

University of Texas Medical Branch

🇺🇸

Galveston, Texas, United States

Tyler Cancer Center

🇺🇸

Tyler, Texas, United States

Utah Cancer Specialists at UCS Cancer Center

🇺🇸

Salt Lake City, Utah, United States

Dixie Regional Medical Center - East Campus

🇺🇸

Saint George, Utah, United States

LDS Hospital

🇺🇸

Salt Lake City, Utah, United States

Norris Cotton Cancer Center - North

🇺🇸

Saint Johnsbury, Vermont, United States

CCOP - Virginia Mason Research Center

🇺🇸

Seattle, Washington, United States

CCOP - Northwest

🇺🇸

Tacoma, Washington, United States

Bay Area Cancer Care Center at Bay Area Medical Center

🇺🇸

Marinette, Wisconsin, United States

Langlade Memorial Hospital

🇺🇸

Antigo, Wisconsin, United States

Beloit Memorial Hospital

🇺🇸

Beloit, Wisconsin, United States

Bellin Memorial Hospital

🇺🇸

Green Bay, Wisconsin, United States

St. Vincent Hospital Regional Cancer Center

🇺🇸

Green Bay, Wisconsin, United States

Columbia Saint Mary's Hospital - Ozaukee

🇺🇸

Mequon, Wisconsin, United States

Riverview UW Cancer Center at Riverview Hospital

🇺🇸

Wisconsin Rapids, Wisconsin, United States

Franciscan Skemp Healthcare - La Crosse Campus

🇺🇸

La Crosse, Wisconsin, United States

Waukesha Memorial Hospital Regional Cancer Center

🇺🇸

Waukesha, Wisconsin, United States

Aurora Medical Center

🇺🇸

Summit, Wisconsin, United States

Cancer Care Program at Thunder Bay Regional Health Sciences

🇨🇦

Thunder Bay, Ontario, Canada

Rocky Mountain Oncology

🇺🇸

Casper, Wyoming, United States

Saint John Regional Hospital

🇨🇦

Saint John, New Brunswick, Canada

Pamela Youde Nethersole Eastern Hospital

🇨🇳

Hong Kong, China

Hopital Notre-Dame du CHUM

🇨🇦

Montreal, Quebec, Canada

Rabin Medical Center - Beilinson Campus

🇮🇱

Petach Tikva, Israel

Tel-Aviv Sourasky Medical Center

🇮🇱

Tel Aviv, Israel

Allan Blair Cancer Centre at Pasqua Hospital

🇨🇦

Regina, Saskatchewan, Canada

UAB Comprehensive Cancer Center

🇺🇸

Birmingham, Alabama, United States

St. Anthony Central Hospital

🇺🇸

Denver, Colorado, United States

Presbyterian - St. Luke's Medical Center

🇺🇸

Denver, Colorado, United States

St. Joseph Hospital

🇺🇸

Denver, Colorado, United States

Legacy Good Samaritan Hospital & Comprehensive Cancer Center

🇺🇸

Portland, Oregon, United States

Mayo Clinic Cancer Center

🇺🇸

Rochester, Minnesota, United States

Tom Baker Cancer Centre - Calgary

🇨🇦

Calgary, Alberta, Canada

Maisonneuve-Rosemont Hospital

🇨🇦

Montreal, Quebec, Canada

CHUS-Hopital Fleurimont

🇨🇦

Sherbrooke, Quebec, Canada

Mercy and Unity Cancer Center at Unity Hospital

🇺🇸

Fridley, Minnesota, United States

HealthEast Cancer Care at St. John's Hospital

🇺🇸

Maplewood, Minnesota, United States

Hennepin County Medical Center - Minneapolis

🇺🇸

Minneapolis, Minnesota, United States

Minnesota Oncology - Maplewood

🇺🇸

Maplewood, Minnesota, United States

St. Francis Cancer Center at St. Francis Medical Center

🇺🇸

Shakopee, Minnesota, United States

Ridgeview Medical Center

🇺🇸

Waconia, Minnesota, United States

Minnesota Oncology - Woodbury

🇺🇸

Woodbury, Minnesota, United States

Cancer Center of Kansas, PA - Winfield

🇺🇸

Winfield, Kansas, United States

University Radiation Oncology at Parkridge Hospital

🇺🇸

Rochester, New York, United States

Veterans Affairs Medical Center - Long Beach

🇺🇸

Long Beach, California, United States

Auburn Radiation Oncology

🇺🇸

Auburn, California, United States

Sutter Health - Western Division Cancer Research Group

🇺🇸

Novato, California, United States

Radiation Oncology Center - Roseville

🇺🇸

Roseville, California, United States

Sentara Cancer Institute at Sentara Norfolk General Hospital

🇺🇸

Norfolk, Virginia, United States

Naval Medical Center - Portsmouth

🇺🇸

Portsmouth, Virginia, United States

Hurley Medical Center

🇺🇸

Flint, Michigan, United States

Bronson Methodist Hospital

🇺🇸

Kalamazoo, Michigan, United States

Van Elslander Cancer Center at St. John Hospital and Medical Center

🇺🇸

Grosse Pointe Woods, Michigan, United States

Door County Cancer Center at Door County Memorial Hospital

🇺🇸

Sturgeon Bay, Wisconsin, United States

Ingalls Cancer Care Center at Ingalls Memorial Hospital

🇺🇸

Harvey, Illinois, United States

Tulane Cancer Center Office of Clinical Research

🇺🇸

Alexandria, Louisiana, United States

Radiological Associates of Sacramento Medical Group, Incorporated

🇺🇸

Sacramento, California, United States

University of California Davis Cancer Center

🇺🇸

Sacramento, California, United States

Mercy General Hospital

🇺🇸

Sacramento, California, United States

Rocky Mountain Cancer Centers - Aurora

🇺🇸

Aurora, Colorado, United States

University of Colorado Cancer Center at UC Health Sciences Center

🇺🇸

Aurora, Colorado, United States

Saint Joseph Mercy Cancer Center

🇺🇸

Ann Arbor, Michigan, United States

CCOP - Michigan Cancer Research Consortium

🇺🇸

Ann Arbor, Michigan, United States

University of Michigan Comprehensive Cancer Center

🇺🇸

Ann Arbor, Michigan, United States

CCOP - Missouri Valley Cancer Consortium

🇺🇸

Omaha, Nebraska, United States

Methodist Estabrook Cancer Center

🇺🇸

Omaha, Nebraska, United States

Immanuel Medical Center

🇺🇸

Omaha, Nebraska, United States

Alegant Health Cancer Center at Bergan Mercy Medical Center

🇺🇸

Omaha, Nebraska, United States

Lakeside Hospital

🇺🇸

Omaha, Nebraska, United States

Creighton University Medical Center

🇺🇸

Omaha, Nebraska, United States

Vince Lombardi Cancer Clinic at Aurora St. Luke's Medical Center

🇺🇸

Milwaukee, Wisconsin, United States

Medical College of Wisconsin Cancer Center

🇺🇸

Milwaukee, Wisconsin, United States

Veterans Affairs Medical Center - Milwaukee

🇺🇸

Milwaukee, Wisconsin, United States

Arizona Center for Cancer Care - Peoria

🇺🇸

Peoria, Arizona, United States

Arizona Oncology - Tucson

🇺🇸

Tucson, Arizona, United States

Valley Medical Oncology

🇺🇸

Fremont, California, United States

Valley Medical Oncology Consultants - Castro Valley

🇺🇸

Castro Valley, California, United States

Rebecca and John Moores UCSD Cancer Center

🇺🇸

La Jolla, California, United States

California Cancer Center - Woodward Park Office

🇺🇸

Fresno, California, United States

Washington Township Hospital

🇺🇸

Fremont, California, United States

Cancer Care Associates

🇺🇸

Fresno, California, United States

Alta Bates Summit Medical Center - Summit Campus

🇺🇸

Oakland, California, United States

CCOP - Bay Area Tumor Institute

🇺🇸

Oakland, California, United States

Feather River Hospital Cancer Center

🇺🇸

Paradise, California, United States

Aurora Presbyterian Hospital

🇺🇸

Aurora, Colorado, United States

Doctors Medical Center - San Pablo Campus

🇺🇸

San Pablo, California, United States

Sutter Solano Medical Center

🇺🇸

Vallejo, California, United States

Porter Adventist Hospital

🇺🇸

Denver, Colorado, United States

Boulder Community Hospital

🇺🇸

Boulder, Colorado, United States

North Suburban Medical Center

🇺🇸

Thornton, Colorado, United States

McKee Medical Center

🇺🇸

Loveland, Colorado, United States

Hope Cancer Care Center at Longmont United Hospital

🇺🇸

Longmont, Colorado, United States

William W. Backus Hospital

🇺🇸

Norwich, Connecticut, United States

Exempla Lutheran Medical Center

🇺🇸

Wheat Ridge, Colorado, United States

Washington Cancer Institute at Washington Hospital Center

🇺🇸

Washington, District of Columbia, United States

CCOP - Christiana Care Health Services

🇺🇸

Newark, Delaware, United States

George Bray Cancer Center at the Hospital of Central Connecticut - New Britain Campus

🇺🇸

New Britain, Connecticut, United States

Integrated Community Oncology Network at Southside Cancer Center

🇺🇸

Jacksonville, Florida, United States

Baptist Medical Center South

🇺🇸

Jacksonville, Florida, United States

Florida Cancer Center - Palatka

🇺🇸

Palatka, Florida, United States

Veterans Affairs Medical Center - Tampa

🇺🇸

Tampa, Florida, United States

Emory Crawford Long Hospital

🇺🇸

Atlanta, Georgia, United States

Piedmont Hospital

🇺🇸

Atlanta, Georgia, United States

Winship Cancer Institute of Emory University

🇺🇸

Atlanta, Georgia, United States

John B. Amos Cancer Center

🇺🇸

Columbus, Georgia, United States

Northside Hospital-Forsyth

🇺🇸

Cumming, Georgia, United States

Piedmont Fayette Hospital

🇺🇸

Fayetteville, Georgia, United States

Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler

🇺🇸

Savannah, Georgia, United States

Kapiolani Medical Center at Pali Momi

🇺🇸

'Aiea, Hawaii, United States

Cardinal Bernardin Cancer Center at Loyola University Medical Center

🇺🇸

Maywood, Illinois, United States

Trinity Cancer Center at Trinity Medical Center - 7th Street Campus

🇺🇸

Moline, Illinois, United States

Elkhart General Hospital

🇺🇸

Elkhart, Indiana, United States

Saint Joseph Regional Medical Center

🇺🇸

Mishawaka, Indiana, United States

CCOP - Northern Indiana CR Consortium

🇺🇸

South Bend, Indiana, United States

Siouxland Hematology-Oncology Associates, LLP

🇺🇸

Sioux City, Iowa, United States

Cancer Center of Kansas, PA - Wellington

🇺🇸

Wellington, Kansas, United States

Lawrence Memorial Hospital

🇺🇸

Lawrence, Kansas, United States

Mary Bird Perkins Cancer Center - Baton Rouge

🇺🇸

Baton Rouge, Louisiana, United States

Greater Baltimore Medical Center Cancer Center

🇺🇸

Baltimore, Maryland, United States

Tate Cancer Center at Baltimore Washington Medical Center

🇺🇸

Glen Burnie, Maryland, United States

Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute

🇺🇸

Boston, Massachusetts, United States

Holy Cross Hospital

🇺🇸

Silver Spring, Maryland, United States

Borgess Medical Center

🇺🇸

Kalamazoo, Michigan, United States

West Michigan Cancer Center

🇺🇸

Kalamazoo, Michigan, United States

Sparrow Regional Cancer Center

🇺🇸

Lansing, Michigan, United States

William Beaumont Hospital - Royal Oak Campus

🇺🇸

Royal Oak, Michigan, United States

St. Mary Mercy Hospital

🇺🇸

Livonia, Michigan, United States

St. Joseph Mercy Oakland

🇺🇸

Pontiac, Michigan, United States

Mercy Regional Cancer Center at Mercy Hospital

🇺🇸

Port Huron, Michigan, United States

Seton Cancer Institute at Saint Mary's - Saginaw

🇺🇸

Saginaw, Michigan, United States

Lakeland Regional Cancer Care Center - St. Joseph

🇺🇸

Saint Joseph, Michigan, United States

MeritCare Bemidji

🇺🇸

Bemidji, Minnesota, United States

St. John Macomb Hospital

🇺🇸

Warren, Michigan, United States

Mercy and Unity Cancer Center at Mercy Hospital

🇺🇸

Coon Rapids, Minnesota, United States

Fairview Ridges Hospital

🇺🇸

Burnsville, Minnesota, United States

Humphrey Cancer Center at North Memorial Outpatient Center

🇺🇸

Robbinsdale, Minnesota, United States

Willmar Cancer Center at Rice Memorial Hospital

🇺🇸

Willmar, Minnesota, United States

Regional Cancer Center at Singing River Hospital

🇺🇸

Pascagoula, Mississippi, United States

Cancer Institute of Cape Girardeau, LLC

🇺🇸

Cape Girardeau, Missouri, United States

CCOP - Montana Cancer Consortium

🇺🇸

Billings, Montana, United States

Bozeman Deaconess Cancer Center

🇺🇸

Bozeman, Montana, United States

Billings Clinic - Downtown

🇺🇸

Billings, Montana, United States

Cancer Resource Center - Lincoln

🇺🇸

Lincoln, Nebraska, United States

Sletten Cancer Institute at Benefis Healthcare

🇺🇸

Great Falls, Montana, United States

Nebraska Medical Center

🇺🇸

Omaha, Nebraska, United States

Memorial Sloan-Kettering Cancer Center - Basking Ridge

🇺🇸

Basking Ridge, New Jersey, United States

Center for Cancer Care at Exeter Hospital

🇺🇸

Exeter, New Hampshire, United States

Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center

🇺🇸

Lebanon, New Hampshire, United States

Kingsbury Center for Cancer Care at Cheshire Medical Center

🇺🇸

Keene, New Hampshire, United States

AtlantiCare Cancer Care Institute at AtlantiCare Regional Medical Center - Mainland Campus

🇺🇸

Galloway, New Jersey, United States

Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School

🇺🇸

New Brunswick, New Jersey, United States

Capital Health Regional Cancer Center

🇺🇸

Pennington, New Jersey, United States

Saint Peter's University Hospital

🇺🇸

New Brunswick, New Jersey, United States

Cancer Institute of New Jersey at Cooper - Voorhees

🇺🇸

Voorhees, New Jersey, United States

Fox Chase Virtua Health Cancer Program at Virtua West Jersey

🇺🇸

Voorhees, New Jersey, United States

Roswell Park Cancer Institute

🇺🇸

Buffalo, New York, United States

Stich Radiation Center at NewYork-Presbyterian Hospital/Weill Cornell Medical Center

🇺🇸

New York, New York, United States

Hudson Valley Oncology Associates

🇺🇸

Poughkeepsie, New York, United States

St. Luke's - Roosevelt Hospital Center - St.Luke's Division

🇺🇸

New York, New York, United States

Dyson Center for Cancer Care at Vassar Brothers Medical Center

🇺🇸

Poughkeepsie, New York, United States

James P. Wilmot Cancer Center at University of Rochester Medical Center

🇺🇸

Rochester, New York, United States

Memorial Sloan-Kettering Cancer Center - Rockville Centre

🇺🇸

Rockville Centre, New York, United States

Mission Hospitals - Memorial Campus

🇺🇸

Asheville, North Carolina, United States

Randolph Hospital

🇺🇸

Asheboro, North Carolina, United States

Blumenthal Cancer Center at Carolinas Medical Center

🇺🇸

Charlotte, North Carolina, United States

Coleman Radiation Oncology Center at Carter General Hospital

🇺🇸

Morehead City, North Carolina, United States

FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center

🇺🇸

Pinehurst, North Carolina, United States

CCOP - MeritCare Hospital

🇺🇸

Fargo, North Dakota, United States

MeritCare Broadway

🇺🇸

Fargo, North Dakota, United States

Summa Center for Cancer Care at Akron City Hospital

🇺🇸

Akron, Ohio, United States

Roger Maris Cancer Center at MeritCare Hospital

🇺🇸

Fargo, North Dakota, United States

Adena Regional Medical Center

🇺🇸

Chillicothe, Ohio, United States

Riverside Methodist Hospital Cancer Care

🇺🇸

Columbus, Ohio, United States

Hematology Oncology Center

🇺🇸

Elyria, Ohio, United States

Grady Memorial Hospital

🇺🇸

Delaware, Ohio, United States

Lima Memorial Hospital

🇺🇸

Lima, Ohio, United States

Community Cancer Center

🇺🇸

Elyria, Ohio, United States

Cleveland Clinic Cancer Center

🇺🇸

Independence, Ohio, United States

Strecker Cancer Center at Marietta Memorial Hospital

🇺🇸

Marietta, Ohio, United States

Hillcrest Cancer Center at Hillcrest Hospital

🇺🇸

Mayfield Heights, Ohio, United States

Lake/University Ireland Cancer Center

🇺🇸

Mentor, Ohio, United States

Northwest Ohio Oncology Center

🇺🇸

Maumee, Ohio, United States

Southwest General Health Center

🇺🇸

Middleburg Heights, Ohio, United States

Licking Memorial Cancer Care Program at Licking Memorial Hospital

🇺🇸

Newark, Ohio, United States

UHHS Chagrin Highlands Medical Center

🇺🇸

Orange Village, Ohio, United States

Parma Community General Hospital

🇺🇸

Parma, Ohio, United States

Cancer Care Center, Incorporated

🇺🇸

Salem, Ohio, United States

Southern Ohio Medical Center Cancer Center

🇺🇸

Portsmouth, Ohio, United States

St. Charles Mercy Hospital

🇺🇸

Oregon, Ohio, United States

Community Hospital of Springfield and Clark County

🇺🇸

Springfield, Ohio, United States

Tony Teramana Cancer Center

🇺🇸

Steubenville, Ohio, United States

Flower Hospital Cancer Center

🇺🇸

Sylvania, Ohio, United States

Toledo Hospital

🇺🇸

Toledo, Ohio, United States

St. Anne Mercy Hospital

🇺🇸

Toledo, Ohio, United States

St. Vincent Mercy Medical Center

🇺🇸

Toledo, Ohio, United States

CCOP - Toledo Community Hospital

🇺🇸

Toledo, Ohio, United States

Toledo Clinic, Incorporated - Main Clinic

🇺🇸

Toledo, Ohio, United States

Mount Carmel St. Ann's Cancer Center

🇺🇸

Westerville, Ohio, United States

UHHS Westlake Medical Center

🇺🇸

Westlake, Ohio, United States

Cancer Treatment Center

🇺🇸

Wooster, Ohio, United States

Genesis - Good Samaritan Hospital

🇺🇸

Zanesville, Ohio, United States

Cleveland Clinic - Wooster

🇺🇸

Wooster, Ohio, United States

Natalie Warren Bryant Cancer Center at St. Francis Hospital

🇺🇸

Tulsa, Oklahoma, United States

Willamette Valley Cancer Center - Eugene

🇺🇸

Eugene, Oregon, United States

Three Rivers Community Hospital

🇺🇸

Grants Pass, Oregon, United States

Geisinger Cancer Institute at Geisinger Health

🇺🇸

Danville, Pennsylvania, United States

UPMC Cancer Center at Jefferson Regional Medical Center

🇺🇸

Clairton, Pennsylvania, United States

UPMC Cancer Center at Beaver Medical Center

🇺🇸

Beaver, Pennsylvania, United States

Adams Cancer Center

🇺🇸

Gettysburg, Pennsylvania, United States

Lancaster General Hospital

🇺🇸

Lancaster, Pennsylvania, United States

UPMC Cancer Center at UPMC McKeesport

🇺🇸

McKeesport, Pennsylvania, United States

Upper Delaware Valley Cancer Center

🇺🇸

Milford, Pennsylvania, United States

Jameson Memorial Hospital - North Campus

🇺🇸

New Castle, Pennsylvania, United States

Fox Chase Cancer Center - Philadelphia

🇺🇸

Philadelphia, Pennsylvania, United States

Cancer Center of Paoli Memorial Hospital

🇺🇸

Paoli, Pennsylvania, United States

Albert Einstein Cancer Center

🇺🇸

Philadelphia, Pennsylvania, United States

St. Joseph Medical Center

🇺🇸

Reading, Pennsylvania, United States

McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center

🇺🇸

Reading, Pennsylvania, United States

Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center

🇺🇸

Wilkes-Barre, Pennsylvania, United States

Lankenau Cancer Center at Lankenau Hospital

🇺🇸

Wynnewood, Pennsylvania, United States

York Cancer Center at Apple Hill Medical Center

🇺🇸

York, Pennsylvania, United States

AnMed Cancer Center

🇺🇸

Anderson, South Carolina, United States

Cancer Centers of the Carolinas - Grove Commons

🇺🇸

Greenville, South Carolina, United States

Hilton Head Radiation Oncology Center

🇺🇸

Hilton Head Island, South Carolina, United States

CCOP - Upstate Carolina

🇺🇸

Spartanburg, South Carolina, United States

Rapid City Regional Hospital

🇺🇸

Rapid City, South Dakota, United States

Gibbs Regional Cancer Center at Spartanburg Regional Medical Center

🇺🇸

Spartanburg, South Carolina, United States

Texas Oncology, PA at Texas Cancer Center - Denton South

🇺🇸

Denton, Texas, United States

Klabzuba Cancer Center at Harris Methodist Fort Worth Hospital

🇺🇸

Fort Worth, Texas, United States

Texas Oncology, PA at Harris Center HEB

🇺🇸

Bedford, Texas, United States

Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas

🇺🇸

Dallas, Texas, United States

Longview Cancer Center

🇺🇸

Longview, Texas, United States

Texas Oncology, PA at Texas Oncology Cancer Center Sugar Land

🇺🇸

Sugar Land, Texas, United States

Sandra L. Maxwell Cancer Center

🇺🇸

Cedar City, Utah, United States

Texas Oncology, PA - Wichita Falls

🇺🇸

Wichita Falls, Texas, United States

Jon and Karen Huntsman Cancer Center at Intermountain Medical Center

🇺🇸

Murray, Utah, United States

Logan Regional Hospital

🇺🇸

Logan, Utah, United States

Utah Valley Regional Medical Center - Provo

🇺🇸

Provo, Utah, United States

Fletcher Allen Health Care - University Health Center Campus

🇺🇸

Burlington, Vermont, United States

INOVA Alexandria Hospital

🇺🇸

Alexandria, Virginia, United States

St. Joseph Cancer Center

🇺🇸

Bellingham, Washington, United States

Virginia Mason Medical Center

🇺🇸

Seattle, Washington, United States

Martha Jefferson Hospital Cancer Care Center

🇺🇸

Charlottesville, Virginia, United States

Danville Regional Medical Center

🇺🇸

Danville, Virginia, United States

St. Francis Hospital

🇺🇸

Federal Way, Washington, United States

Coastal Cancer Center at Sentara Virginia Beach General Hospital

🇺🇸

Virginia Beach, Virginia, United States

Good Samaritan Cancer Center

🇺🇸

Puyallup, Washington, United States

Franciscan Cancer Center at St. Joseph Medical Center

🇺🇸

Tacoma, Washington, United States

North Star Lodge Cancer Center at Yakima Valley Memorial Hospital

🇺🇸

Yakima, Washington, United States

Cancer Care Northwest - Spokane South

🇺🇸

Spokane, Washington, United States

Legacy Salmon Creek Medical Center

🇺🇸

Vancouver, Washington, United States

MultiCare Regional Cancer Center at Tacoma General Hospital

🇺🇸

Tacoma, Washington, United States

West Virginia University Health Sciences Center - Charleston

🇺🇸

Charleston, West Virginia, United States

Fox Valley Hematology and Oncology - East Grant Street

🇺🇸

Appleton, Wisconsin, United States

Theda Care Cancer Institute

🇺🇸

Appleton, Wisconsin, United States

Columbia-Saint Mary's Water Tower Medical Commons

🇺🇸

Milwaukee, Wisconsin, United States

Gundersen Lutheran Center for Cancer and Blood

🇺🇸

La Crosse, Wisconsin, United States

Central Wisconsin Cancer Program at Agnesian HealthCare

🇺🇸

Fond Du Lac, Wisconsin, United States

Community Memorial Hospital Cancer Care Center

🇺🇸

Menomonee Falls, Wisconsin, United States

All Saints Cancer Center at Wheaton Franciscan Healthcare

🇺🇸

Racine, Wisconsin, United States

University of Wisconcin Cancer Center at Aspirus Wausau Hospital

🇺🇸

Wausau, Wisconsin, United States

London Regional Cancer Program at London Health Sciences Centre

🇨🇦

London, Ontario, Canada

D.N. Greenwald Center

🇺🇸

Mukwonago, Wisconsin, United States

West Allis Memorial Hospital

🇺🇸

West Allis, Wisconsin, United States

Regional Cancer Center at Oconomowoc Memorial Hospital

🇺🇸

Oconomowoc, Wisconsin, United States

Doctor H. Bliss Murphy Cancer Centre

🇨🇦

Saint John's, Newfoundland and Labrador, Canada

Centre Hospitalier Universitaire de Quebec

🇨🇦

Quebec City, Quebec, Canada

Saskatoon Cancer Centre at the University of Saskatchewan

🇨🇦

Saskatoon, Saskatchewan, Canada

Norton Suburban Hospital

🇺🇸

Louisville, Kentucky, United States

Florida Hospital Cancer Institute at Florida Hospital Orlando

🇺🇸

Orlando, Florida, United States

Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center

🇺🇸

Hershey, Pennsylvania, United States

Saint Elizabeth Cancer Institute at Saint Elizabeth Regional Medical Center

🇺🇸

Lincoln, Nebraska, United States

Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill

🇺🇸

Chapel Hill, North Carolina, United States

Hollings Cancer Center at Medical University of South Carolina

🇺🇸

Charleston, South Carolina, United States

University of Florida Shands Cancer Center

🇺🇸

Gainesville, Florida, United States

Cancer Research Center of Hawaii

🇺🇸

Honolulu, Hawaii, United States

Queen's Cancer Institute at Queen's Medical Center

🇺🇸

Honolulu, Hawaii, United States

Straub Clinic and Hospital, Incorporated

🇺🇸

Honolulu, Hawaii, United States

Hawaii Medical Center - East

🇺🇸

Honolulu, Hawaii, United States

CCOP - Iowa Oncology Research Association

🇺🇸

Des Moines, Iowa, United States

John Stoddard Cancer Center at Iowa Methodist Medical Center

🇺🇸

Des Moines, Iowa, United States

Medical Oncology and Hematology Associates at John Stoddard Cancer Center

🇺🇸

Des Moines, Iowa, United States

Medical Oncology and Hematology Associates at Mercy Cancer Center

🇺🇸

Des Moines, Iowa, United States

Mercy Cancer Center at Mercy Medical Center - Des Moines

🇺🇸

Des Moines, Iowa, United States

John Stoddard Cancer Center at Iowa Lutheran Hospital

🇺🇸

Des Moines, Iowa, United States

Lucille P. Markey Cancer Center at University of Kentucky

🇺🇸

Lexington, Kentucky, United States

MBCCOP - LSU Health Sciences Center

🇺🇸

New Orleans, Louisiana, United States

Medical Center of Louisiana - New Orleans

🇺🇸

New Orleans, Louisiana, United States

CCOP - Ochsner

🇺🇸

New Orleans, Louisiana, United States

New Mexico Cancer Center

🇺🇸

Albuquerque, New Mexico, United States

University of New Mexico Cancer Center

🇺🇸

Albuquerque, New Mexico, United States

Veterans Affairs Medical Center - Richmond

🇺🇸

Richmond, Virginia, United States

University of Wisconsin Paul P. Carbone Comprehensive Cancer Center

🇺🇸

Madison, Wisconsin, United States

Cross Cancer Institute at University of Alberta

🇨🇦

Edmonton, Alberta, Canada

Highland Hospital of Rochester

🇺🇸

Rochester, New York, United States

St. Joseph Hospital Regional Cancer Center - Orange

🇺🇸

Orange, California, United States

Fairview Southdale Hospital

🇺🇸

Edina, Minnesota, United States

Margaret and Charles Juravinski Cancer Centre

🇨🇦

Hamilton, Ontario, Canada

Foote Memorial Hospital

🇺🇸

Jackson, Michigan, United States

Cancer Center of Kansas, PA - El Dorado

🇺🇸

El Dorado, Kansas, United States

Franklin & Edith Scarpa Regional Cancer Center at South Jersey Healthcare

🇺🇸

Vineland, New Jersey, United States

Northeast Radiation Oncology Center

🇺🇸

Dunmore, Pennsylvania, United States

Texas Oncology, PA at Texas Cancer Center - Sherman

🇺🇸

Sherman, Texas, United States

Barnes-Jewish West County Hospital

🇺🇸

Saint Louis, Missouri, United States

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