Comparison of different treatments in the management of recurrent herpes labialis
Not Applicable
Completed
- Conditions
- Patients with recurrent herpes labialisInfections and Infestations
- Registration Number
- ISRCTN87606522
- Lead Sponsor
- Damascus University
- Brief Summary
2024 Results article in https://pubmed.ncbi.nlm.nih.gov/38376628/ (added 21/02/2024)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
1. Good general health
2. 18 years of age or older
3. Recurrent herpes labialis in the vesicular stage
4. Other treatments for the present lesion
Exclusion Criteria
1. Pregnant and lactating
2. Patients who took antiviral drugs during the four weeks preceding treatment
3. Patients who took anti-inflammatory drugs or antibiotics during the two weeks preceding treatment
4. Diabetes
5. Patients with skin injuries that affect the course of healing or interfere with the results of the study
6. Patients who have allergic reactions to the medications used
7. Immunocompromised patients
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome measures are assessed at baseline (T0: Before taking any action in the first session) and at the following time points:<br>1. Pain measured using a visual analogue scale (VAS) <br>2. Healing speed measured using study records of the day the crust of the lesion falls off spontaneously<br><br><br>T1: After applying the laser (activated or placebo) in the first session<br>T2: The second session (after 48 hours) before applying the laser (activated or placebo)<br>T3: The second session after applying the laser (activated or placebo)<br>T4: Third session after 7 days. The day when the pain has completely disappeared is also recorded.
- Secondary Outcome Measures
Name Time Method Pain measured using a VAS on day 7