Effect of HRS-8427 for Injection on the Pharmacokinetics of Furosemide and Metformin in Healthy Subjects。

Jiangsu HengRui Medicine Co., Ltd.1 个研究点分布在 1 个国家目标入组 24 人开始时间: 2025年7月15日最近更新: 2025年8月28日

适应症

干预措施

试验速览

阶段: 1 期
状态: 已完成
发起方: Jiangsu HengRui Medicine Co., Ltd.
入组人数: 24
试验地点: 1
主要终点: Cmax

研究概览研究设计入排标准研究组 & 干预措施结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

The pharmacokinetics of HRS-8427 for injection on the transporter OAT1 substrate furosemide and the MATE1/METE2-K substrate metformin were evaluated in healthy subjects. The safety of HRS-8427 for injection was evaluated in combination with furosemide and metformin.

研究设计

研究类型: Interventional
分配方式: Non Randomized
干预模型: Parallel
主要目的: Treatment
盲法: None

入排标准

年龄范围: 18 Years 至 45 Years（Adult）
性别: All
接受健康志愿者: 是

入选标准

•Healthy male and female subjects aged from 18 to 45 years old (including 18 and 45 years old, subject to the time of signing the informed consent)
•Body weight ≥45 kg for female subjects and ≥50 kg for male subjects with body mass index (BMI) in the range of 19.0-26.0 kg/m2 (BMI = weight (kg)/height 2 (m2)), including boundary values
•Female subjects were not pregnant or lactating and had a negative pretrial pregnancy test. Male or female subjects agreed to use a highly effective contraceptive method approved by the investigator as required by the investigator (see Appendix 13 to the protocol) for the duration of the trial, with no sperm/egg donation planned (from the time of informed consent until 3 months after the last dose).
•have understood the nature, significance, possible benefits, possible inconvenience and potential risks of the trial in detail before the trial, and voluntarily participate in the clinical trial, can communicate well with the investigators, comply with the requirements of the whole study, and sign the written informed consent

排除标准

•Have a history of food or drug allergy
•previous or current diseases of the heart, liver, kidney, endocrine, digestive tract, immune system, respiratory system, musculoskeletal system, and nervous system
•Plasma concentrations of sodium, potassium, magnesium and calcium were lower than the normal range and serum creatinine was not in the normal range
•Patients with fasting blood glucose below the normal range or a history of hypoglycemia.
•Abnormal 12-lead electrocardiogram and the investigator's judgment that the patient is not suitable for the study (including but not limited to QTcF > 450 ms, severe arrhythmia such as atrioventricular block of degree II or above)
•Laboratory tests (blood routine test, urine routine test, urine sediment test, blood biochemistry, coagulation function test, thyroid function test), physical examination, vital signs (temperature, blood pressure, pulse), abdominal ultrasound and chest X-ray results were judged by clinicians as clinically significant abnormalities。
•Infectious disease tests (human immunodeficiency virus antibody, hepatitis B surface antigen, anti-hepatitis C virus antibody, anti-treponema pallidum specific antibody) were positive。
•Patients who underwent major surgery within 3 months before screening; Or underwent surgery that may affect the in vivo course or safety evaluation of the study drug; Or planned to undergo surgery during the study period。
•Participants who had been enrolled in a drug clinical trial within 3 months before screening and had taken a trial drug, or who planned to participate in another clinical trial during the study period。
•Participants who had donated blood or had a blood loss of more than 300 mL or received a transfusion or blood product within 3 months before screening or were scheduled to donate blood during or within 1 month after the trial。
•Those who had a history of drug abuse within 3 months before screening, had a history of drug use, or had a positive screening test for drug abuse。
•The participant had any other factor that was deemed by the investigator to preclude participation in the trial

研究组 & 干预措施

HRS-8427 injection plus furosemide

Experimental

干预措施: HRS-8427 injection plus furosemide (Drug)

HRS-8427 injection plus metformin

Experimental

干预措施: HRS-8427 injection plus metformin (Drug)