Effect of Different Bran-based Dietary Platforms on the Colon Metabolism in Healthy Volunteers
Not Applicable
Completed
- Conditions
- Healthy
- Registration Number
- NCT02422537
- Lead Sponsor
- KU Leuven
- Brief Summary
During this project the effect of 3 different bran-based dietary platforms on the fermentation on a readily fermentable substrate will be investigated using stable isotope techniques.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 10
Inclusion Criteria
- Healthy
- Aged between 18 and 65 years
- BMI between 18 and 27 kg/m²
- Stable eating pattern (3 meals/day on at least 5 days/week)
Exclusion Criteria
- Use of antibiotics in the month preceding the study
- Abdominal surgery (except from appendectomy)
- Use of medication that affects the gastrointestinal tract during the last 2 weeks prior to the study including spasmolytics, anti-diarrhoea medication, anti-constipation medication
- Use of pre- or probiotic supplements in the month preceding the study
- Chronic gastrointestinal diseases, such as inflammatory bowel disease (Crohn's disease, ulcerative colitis), irritable bowel disease...
- Pregnancy or lactation
- Blood donation in the last 3 months
- Abnormal Hb-level (Standard range between 14 and 18 g/dL for men and between 12 and 16 g/dL for women)
- Participation in clinical studies involving radiation exposure in the past year
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Quantification of acetate, propionate and butyrate production in the colon after consumption of each bran-based dietary platform 2 years
- Secondary Outcome Measures
Name Time Method Estimation of the site of fermentation of a readily fermentable carbohydrate in the presence of different bran-based dietary platforms 2 years
Trial Locations
- Locations (1)
KU Leuven/ UZ Leuven
🇧🇪Leuven, Vlaams-Brabant, Belgium
KU Leuven/ UZ Leuven🇧🇪Leuven, Vlaams-Brabant, Belgium