Renal Resistive index as a predictor of acute kidney injury in patients undergoing living donor liver transplantation – a prospective observational study
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- increase in RRI will preceede the changes in creatinine and will help to predict AKI early
Study Overview
Brief Summary
This is a prospective observational study to find out the role of measuring renal resistive index in predicting acute kidney injuryin patients undergoing living donor liver transplantation surgeries. The renal resistive index (RRI) is a non-invasive ultrasonographic Doppler tool which measures blood flow velocity in intra-parenchymal renal arteries. Normal values are reported between 0.60 to 0.70 with the difference between both kidneys being mostly less than 5%. Tacrolimus is one of the drugs used in immunosuppressive therapy of organ transplant recipients and its potency has been proven in treating early graft dysfunction, graft loss, acute rejection, new onset diabetes after transplant and hypertension.
Study population includes those who are above 18years of age. Total sample size is 100. These patients RRI is measured pre operatively and follow up til POD 05 along with tacrolimus trough level, renal function biochemical parameters, eGFR, urine output etc.
Our secondary objective is to find the association with tacrolimus trough levels,eGFR along with RRI in predicting AKI.
Study Design
- Study Type
- Observational
Eligibility Criteria
- Ages
- 18.00 Year(s) to 99.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •1.To assess whether RRI could predict acute kidney injury in the post-operative period in patients undergoing living donor liver transplantation.
Exclusion Criteria
- •1.To find the correlation between trough tacrolimus levels and RRI.
- •2.To find the association between urea, creatinine, estimated glomerular filtration rate and RRI.
- •3.To assess whether RRI could predict recovery from acute kidney injury.
- •4.To assess the changes in RRI and its association with patient outcomes – sepsis, mechanical ventilation, wound infection, length of ICU stay and hospital stay.
Outcomes
Primary Outcomes
increase in RRI will preceede the changes in creatinine and will help to predict AKI early
Time Frame: Pre operative day, POST OPERATIVE 01 TO POST OPERATIVE 05
Secondary Outcomes
- Association between RRI & Tacrolimus trough levels(Association of RRI with blood Urea,s.creat, eGFR)