Microbiota Profile in Heart Failure and Heart Transplant

Girish Dwivedi0 sites200 target enrollmentDecember 11, 2019

Overview

No summary available.

Registry

who.int

Start Date

December 11, 2019

End Date

TBD

Last Updated

6 years ago

Study Type

Observational

Sex

All

Sponsor

Girish Dwivedi

•Men and women between 40– 80 years of age presenting to Fiona Stanley Hospital with heart failure will be recruited for the study. Healthy family members of patients will be invited to take part in the study and will act as environmental controls and will be age matched where possible.
•The participant to present to FSH with heart failure
•Healthy participants will be relatives of heart failure patients and are defined as individuals
•with no clinically relevant abnormalities identified by a detailed medical history, full
•physical examination including blood pressure, heart rate, clinical lab tests from a
•fasting blood sample
•Evidence of a personally signed and dated informed consent document indicating that
•the participant has been informed of all pertinent aspects of the trial
•Willing and able to comply with study procedures, i.e. sample collection

•Participants will be excluded from the study:
•If there are circumstances that interfere with the participant’s ability to give informed
•consent (e.g. diminished understanding, or proficiency in English language and an
•interpreter unavailable)
•Participants taking probiotics, antibiotics or antivirals which may disrupt gut
•microbiota environment, current or recent \<3 months.
•Major chronic disease e.g. cancer or dementia
•Healthy participants will be excluded if they have a history of major chronic disease
•(including cardiovascular disease, psychiatric illness, cancer, diabetes), BMI \<18 or
•\>35 kg/m2, current or recent (\<12 months) smoking, current or recent (\<6 months)