Microbiota Profile in Heart Failure and Heart Transplant

Girish Dwivedi0 个研究点目标入组 200 人开始时间: 2019年12月11日最近更新: 2020年1月6日

适应症

试验速览

暂无简介。

•Men and women between 40– 80 years of age presenting to Fiona Stanley Hospital with heart failure will be recruited for the study. Healthy family members of patients will be invited to take part in the study and will act as environmental controls and will be age matched where possible.
•The participant to present to FSH with heart failure
•Healthy participants will be relatives of heart failure patients and are defined as individuals
•with no clinically relevant abnormalities identified by a detailed medical history, full
•physical examination including blood pressure, heart rate, clinical lab tests from a
•fasting blood sample
•Evidence of a personally signed and dated informed consent document indicating that
•the participant has been informed of all pertinent aspects of the trial
•Willing and able to comply with study procedures, i.e. sample collection

•Participants will be excluded from the study:
•If there are circumstances that interfere with the participant’s ability to give informed
•consent (e.g. diminished understanding, or proficiency in English language and an
•interpreter unavailable)
•Participants taking probiotics, antibiotics or antivirals which may disrupt gut
•microbiota environment, current or recent <3 months.
•Major chronic disease e.g. cancer or dementia
•Healthy participants will be excluded if they have a history of major chronic disease
•(including cardiovascular disease, psychiatric illness, cancer, diabetes), BMI <18 or
•>35 kg/m2, current or recent (<12 months) smoking, current or recent (<6 months)
•significant weight loss or gain (>6% body weight), alcohol intake >280g p/week for
•men and >210g p/week for women.
•Inability to comply with study procedure

发起方

Girish Dwivedi