Erythropoietin effect on ischemic_reperfusion injury

Not Applicable

• Conditions: Ischemic reperfusion injury in chronic artery bypass graft surgery.; Chronic ischaemic heart disease; I25.1,I25.

• Registration Number: IRCT2016011621087N1
• Lead Sponsor: Pooyesh Darou company and Shahid Beheshti University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

The inclusion criterion are revascularization requirement according to angiographic evidence,cronary artery bypass graft (CABG) surgery in elective situation, for the first time and with cardiopulmonary bypass(CPB). The exclusion criteria are comprised of history of myocardial infarction in the past 3 months, previous myocardial trauma or major surgery in the past 3 months, Cr>2, receiving streptokinase or previous reperfusion treatments, EPO intake in the recent 6 months, known thrombo-embolic disorder, malignant disease,uncontrolled hypertension and polycythemia

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Interleukin 6. Timepoint: before operation (base),just after operation,24 hours after operation,48 hours after operation. Method of measurement: elisa.;YKL-40. Timepoint: before operation (base),just after operation,24 hours after operation,48 hours after operation. Method of measurement: elisa.;TNF-a. Timepoint: before operation (base),just after operation,24 hours after operation,48 hours after operation. Method of measurement: elisa.;Added at 2016-09-22: B type natriuretic peptide(BNP. Timepoint: before operation (base),just after operation,24 hours after operation,48 hours after operation. Method of measurement: Added at 2016-09-22: ELISA.

Secondary Outcome Measures

Name	Time	Method
CPK-MB. Timepoint: befor operation(base),6 hour after operation,12 hour after operation. Method of measurement: elisa.;Bleeding. Timepoint: during operation,6 hour after operation,12 hour after operation,24 hour after operation. Method of measurement: volume of bleeeding.;Troponin. Timepoint: befor operation(base),6 hour after operation,12 hour after operation. Method of measurement: elisa.