Population Pharmacokinetics of Dexmedetomidine in ICU Patients
- Registration Number
- NCT00714857
- Lead Sponsor
- University of Turku
- Brief Summary
Dexmedetomidine is a new, highly selective and potent alpha2-adrenoreceptor agonist registered for sedation of patients in intensive care units. Although the pharmacokinetics of dexmedetomidine have been studied previously also in an ICU setting, there is no information on the pharmacokinetics of long-lasting (\>48 hours) dexmedetomidine infusions in humans.
The aim of this study is to study the pharmacokinetics of long-lasting dexmedetomidine infusions in ICU patients using the population pharmacokinetics approach.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 21
Inclusion Criteria
- Age ≥ 18 years.
- Need for dexmedetomidine sedation (determined by the responsible physician).
- Predicted length of dexmedetomidine sedation ≥ 48 hours.
- Written informed consent from the patient or the relatives of the participating patient.
Exclusion Criteria
- A previous history of intolerance to the study drug or related compounds and additives.
- Existing significant haematological, endocrine, metabolic or gastrointestinal disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description 1 Dexmedetomidine Patients receiving dexmedetomidine sedation
- Primary Outcome Measures
Name Time Method Pharmacokinetic parameters Blood samples are taken three times daily for characterizing the pharmacokinetic parameters
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Turku University Hospital
🇫🇮Turku, Finland