NCT06521645已完成不适用
The Effect of Acupoint Stimulation on Level of Lactate in Patients Undergoing Cerebral Endovascular Intervention
Air Force Military Medical University, China1 个研究点 分布在 1 个国家目标入组 28 人开始时间: 2024年10月30日最近更新:
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 28
- 试验地点
- 1
- 主要终点
- arterial level of lactate at 30 minutes after recanalization
研究概览
简要总结
It is advocated that neuroprotection should be increased before endovascular treatment and that the penumbra should be protected from reperfusion damage after recanalization. Monitoring lactate and pH levels in acute ischemic stroke patients who have had endovascular recanalization can be utilized to predict mortality and morbidity, especially in the first five hours after the procedure. This study aims to observe the effect of acupoint stimulation on lactate level during endovascular recanalization.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age ≥18 years
- •scheduled for cerebral endovascular intervention
排除标准
- •American Society of Anesthesiologists status over level three
- •history of cerebral vascular intervention
- •history of severe neurological disease (stroke, neurological degenerative disease, psychiatric disease)
- •severe hepatic or renal dysfunction
- •severe glucose disorder or thyroid dysfunction
- •contraindications to transcutaneous electrical stimulation (infection or injury of the skin area, implanted electrical devices)
研究组 & 干预措施
Acupoint stimulation
Experimental
needles are inserted into the skin of Baihui acupoint, and electrical acupoint stimulation is given
干预措施: electroacupuncture (Other)
Control
Sham Comparator
needles are shallowly inserted into the skin of Bihui acupoint, but no electrical acupoint stimulation is given
干预措施: sham needle (Other)
结局指标
主要结局
arterial level of lactate at 30 minutes after recanalization
时间窗: 30 minutes after recanalization
次要结局
- partial pressure of oxygen at 30 minutes after recanalization(30 minutes after recanalization)
- partial pressure of oxygen immediately after recanalization(about 1 minute after recanalization)
- arterial level of lactate immediately after recanalization(about 1 minute after recanalization)
- pH value at 30 minutes after recanalization(30 minutes after recanalization)
- Concentration of HCO3- at 30 minutes after recanalization(30 minutes after recanalization)
- Concentration of base excess at 30 minutes after recanalization(30 minutes after recanalization)
- partial pressure of carbon dioxide at 30 minutes after recanalization(30 minutes after recanalization)
- pH value immediately after recanalization(about 1 minute after recanalization)
- Concentration of HCO3- immediately after recanalization(about 1 minute after recanalization)
- Concentration of base excess immediately after recanalization(about 1 minute after recanalization)
- partial pressure of carbon dioxide immediately after recanalization(about 1 minute after recanalization)
- Concentration of serum interleukin-6 at 30 minutes after recanalization(30 minutes after recanalization)
- Concentration of serum tumor necrosis factor α at 30 minutes after recanalization(30 minutes after recanalization)
- Concentration of serum brain-derived neurotrophic factor at 30 minutes after recanalization(30 minutes after recanalization)
- score of modified Rankin's scale at 24 hours after recanalization(24 hours after recanalization)
- incidence of stroke during hospitalization(From end of surgery to discharge from hospital, at an average of 5 days)
- Incidence of death during hospitalization(From end of surgery to discharge from hospital, at an average of 5 days)
- length of hospitalization(From end of surgery to discharge from hospital, at an average of 5 days)
研究者
Zhihong LU
Associate professor
Air Force Military Medical University, China
研究点 (1)
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