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Clinical Trials/NCT00604370
NCT00604370CompletedNot Applicable

VTE Prophylaxis Across the Continuum of Care: High Risk Patients at Hospital Discharge

Brigham and Women's Hospital0 sites2,500 target enrollmentStarted: February 2008Last updated:
Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Enrollment
2,500
Primary Endpoint
Symptomatic PE/DVT within 90 days of hospital discharge.

Study Overview

Brief Summary

An investigator initiated study exploring VTE prophylaxis at the time of hospital discharge.

Detailed Description

It appears likely that many patients will remain at risk for VTE at the time of hospital discharge. These risks will go unrecognized, and discharge prophylaxis orders will not be prescribed.

To test this hypothesis, we will perform a retrospective review of approximately 2,500 patients at Brigham and Women's Hospital at risk for VTE at the time of hospital discharge to determine what proportion received VTE prophylaxis. We will correlate the implementation of discharge VTE prophylaxis with the occurrence of symptomatic DVT and pulmonary embolism within 90 days of hospital discharge.

We will also conduct a substudy of this patient population to determine adherence to VTE prophylaxis among hospitalized patients.

Study Design

Study Type
Observational
Observational Model
Case Control
Time Perspective
Retrospective

Eligibility Criteria

Ages
17 Years to — (Child, Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Acutely ill medical and surgical patients with a risk score of 4 or greater without prophylaxis or a risk score of 4 or greater with anticoagulation at hospital discharge.

Exclusion Criteria

  • Not provided

Outcomes

Primary Outcomes

Symptomatic PE/DVT within 90 days of hospital discharge.

Time Frame: 90 days

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Samuel Z.Goldhaber, MD

Director, VTE Research Group

Brigham and Women's Hospital

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