Reduction of Natural Killer Cell (CD16/56) and T-lymphocyte (CD3) Subset Counts After a Weight Loss Program Using Anti-obesity Drugs in Obese Women: a Non-randomized Controlled Trial
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 29
- 主要终点
- lymphocyte subgroups
研究概览
简要总结
This study included two groups of premenopausal healthy obese women. Experimental group underwent a weight loss program involved a low calorie diet plus anti-obesity drugs and moderate physical activity and control group underwent an ad libitum diet. At baseline and after a 10-15% weight loss lymphocyte subgroups were analyzed and compared between two group.
详细描述
TCD3 and NKC CD16/56 were decreased significantly. Hence this weight loss program impaired viral immunity
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •BMI >=30
- •no smoking
- •not lactating
- •not pregnant
- •no medication use
排除标准
- •pregnancy
- •any disease
- •any medication use
- •iron and zinc deficiency
- •any supplement use
研究组 & 干预措施
experimental
This group underwent a weight loss program
干预措施: weight loss program (Combination Product)
control
This group underwent adlibitum diet + physical activity
结局指标
主要结局
lymphocyte subgroups
时间窗: 6 months
TCD3. TCD4. TCD8. BCD19. NKCs CD16/56 (Cells/microliter) by flowcytometry
次要结局
- Weight(6 months)
- Biomarkers(6 months)
- Systolic blood pressure(6 months)
- diastolic blood pressure(6 months)
- Fat Free Mass(6 months)
- Waist circumference(6 months)
- Fat Mass(6 months)
- Body Mass Index(6 months)
- Trunk Fat(6 months)
研究者
Mahsa Mehrdad
Principal investigator
Shiraz University of Medical Sciences