VEGF in Iris Tissue in Primary Congenital Glaucoma

Not Applicable

• Conditions: Iris
• Interventions: Other: Immunohistochemistry analysis

• Registration Number: NCT05484050
• Lead Sponsor: Hassan Lotfy Fahmy

Brief Summary

Estimation of vascular endothelial growth factor (VEGF) in iris tissue specimen in primary congenital glaucoma through Immunohistochemistry.

Detailed Description

Combined trabeculotomy with mitomycin C will done in infants with primary congenital glaucoma with histopathological examination of the the peripheral iris tissue specimen and vascular endothelial growth factor (VEGF) estimation in iris tissue specimen through Immunohistochemistry.

Estimation of vascular endothelial growth factor (VEGF) in iris tissue specimen taking from ocular trauma or congenital cataract used as control.

Study Timeline

• Status Verified: 2022-07
• Study First Submitted: 2022-07-22
• Study First Submitted QC: 2022-07-29
• Last Update Submitted: 2022-07-29
• Study First Posted: 2022-08-02
• Last Update Posted: 2022-08-02
• Study Start: 2022-09
• Primary Completion: 2023-03
• Study Completion: 2023-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• primary congenital glaucoma

Exclusion Criteria

• Infants with history of previous surgery.
• Secondary glaucoma.
• Glaucoma associated with other congenital anomalies.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
VEGF in iris tissue in primary congenital glaucoma	Immunohistochemistry analysis	Estimation of VEGF grade in iris tissue in primary congenital glaucoma through Immunohistochemistry
VEGF in iris tissue from ocular trauma or congenital cataract	Immunohistochemistry analysis	Estimation of VEGF grade in iris tissue from ocular trauma or congenital cataract through Immunohistochemistry

Primary Outcome Measures

Name	Time	Method
VEGF	6 month	Estimation of VEGF grade in iris tissue through Immunohistochemistry, The grades is arranged from 0 to 5, with 0 being the lowest level and 5 being the highest level

Trial Locations

Locations (1)

Hassan Lotfy; 🇪🇬 Assiut, Egypt