Pattern of Acute on Chronic Liver Failure in Patient With HCV Related Chronic Liver Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- pattern of acute on chronic liver cell failure
研究概览
简要总结
The concept of acute-on-chronic liver failure (ACLF) was introduced by Jalan and Williams in 2002 to describe the acute deterioration in liver function over 2 to 4 weeks in a patient with well-compensated cirrhosis associated with a precipitating event (hepatotoxic: superimposed hepatitis viral infection, drug-induced liver injury, hepatotoxins, or excessive alcohol consumption; extra hepatic: variceal bleeding or sepsis), leading to severe deterioration in clinical status with jaundice and hepatic encephalopathy and/or HRS. Following this concept, several proposals for the diagnostic criteria of ACLF have been suggested.
详细描述
There may be regional differences in etiology, pathogenesis, and natural course of ACLF, which may in turn influence the overall outcome of this syndrome. So, proper diagnosis of ACLF and its precipitating factors in our locality enable us for proper management of these cases and dealing with these precipitating factors to be avoided later on in patients with liver cirrhosis
Aim of the work:
To identify the pattern of acute on chronic liver cell failure (ACLF) within 28 days including prevalence, percipitating factors, and outcome.
Patients and methods
Type of the study: Prospective hospital based study
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult Patients with HCV related CLD based on clinical, biochemical and imaging evidence., with or without prior decompensation.
- •Patients diagnosed to have ACLIF at any grade (1-3)
排除标准
- •Acute liver failure without evidence of chronic liver disease.
- •Other etiology of chronic liver disease
- •Patients diagnosed with no ACLIF No ACLF
- •This category includes patients who either:
- •Do not have any organ failure
- •Have a single organ failure that does not involve the kidney with a serum creatinine level of <1.5 mg per dl and no hepatic encephalopathy
- •Have a single brain failure with a serum creatinine level of <1.5 mg per dl
- •Patients refuse to participate.
结局指标
主要结局
pattern of acute on chronic liver cell failure
时间窗: march 2018 to march 2019
evaluation of cases with acute on chronic liver cell failure as number of cases diagnosed with ACLF in this period , the precipitating factor of the condition , the fate of the patient (improving or deterioration or death ) in the 28 days following diagnosis .
次要结局
未报告次要终点
研究者
Tasneem Khaled
resident doctor
Assiut University