Application of DWI in Diagnosis of Prostate Cancer

Completed

• Conditions: Benign Prostatic Hyperplasia; Prostate Cancer
• Interventions: Diagnostic Test: MRI

• Registration Number: NCT04962269
• Lead Sponsor: Peking University Third Hospital

Brief Summary

This study compared the performance of different models of multiple b-value DWI in diagnosing prostate cancer.

Detailed Description

Diffusion weighted imaging (DWI) plays an important role in the diagnosis and stratification of prostate cancer. Traditional DWI apply the apparent diffusion coefficient (ADC) to reflect the diffusion of tissue water, which is a parameter calculated by a monoexponential model with 2b values. In recent years, the development of multiple b-value DWI facilitates the appearance of many new mathematical models. Different models have different features, but their value of applications in prostate cancer still need to be confirmed. This study was aiming to: (1) compare the parameters derived from monoexponential model, intravoxel incoherent motion (IVIM) model and stretched exponential model between prostate cancer and benign prostatic hyperplasia; (2) compare the difference of these parameters between low-grade (Gleason score ≤ 3+4) and high-grade (Gleason score ≥ 4+3) cancer; (3) find whether these parameters derived from new models are superior to ADC derived from traditional monoexponetial model.

Study Timeline

• Study Start: 2013-06-12
• Primary Completion: 2018-06-21
• Study Completion: 2018-06-21
• Status Verified: 2021-06
• Study First Submitted: 2021-06-29
• Study First Submitted QC: 2021-07-04
• Last Update Submitted: 2021-07-04
• Study First Posted: 2021-07-14
• Last Update Posted: 2021-07-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 103

Inclusion Criteria

1. The exam including T1WI、T2WI and multiple b-value DWI.
2. Comfired by pathology as prostate cancer or benign prostatic hyperplasia in one month after the MRI exam.

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Exclusion Criteria

• 1.No Gleason score data. 2.Awful quality of imagings or artifacts affectting diagnosis. 3.No lesion larger than 0.5cm. 4.Any surgery or treatment before MRI exam. 5.Biopsy in 4 weeks before MRI exam.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
prostate cancer	MRI	The patient was pathologically diagnosed with prostate cancer

Primary Outcome Measures

Name	Time	Method
pathological diagnosis	2013.10-2018.6	prostate cancer or benign prostatic hyperplasia