Efficacy of oral itraconazole with sertaconazole cream versus oral itraconazole with clotrimazole cream in dermatophytosis - a randomized controlled trial in a tertiary care hospital in Pakista
- Conditions
- Dermatophyte infection.Dermatophytosis
- Registration Number
- IRCT20230531058353N1
- Lead Sponsor
- PNS Shifa
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 118
Patients of both, male and female genders, in age group 12-75 years with clinical manifestations of cutaneous dermatophyte infections (tinea corporis/tinea cruris/tinea faciei) and confirmation done with skin scraping positive for potassium hydroxide (KOH) mount.
Patients with age less than 12 years and greater than 75 years.
Hyperlipidemia
Abnormal liver function tests
Pregnant and breast feeding females.
solitary lesion which is less than 3 cm in diameter
hypersensitivity to antifungals
if patients are on any systemic medications known to have interactions with itraconazole
superadded bacterial infections
patients on immunosuppressive drugs
patients who are known case of liver or renal disease
Tinea capitis and onychomycosis
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Clinical evaluation and absence of fungal hyphae on KOH microscopy. Timepoint: Patients were evaluated clinically on 2 weeks of treatment then 4 weeks of treatment (end point) and then further followed up after 4 weeks. Method of measurement: Clinical evaluation.
- Secondary Outcome Measures
Name Time Method