Acute Cardio-metabolic Responses to Montmorency Tart Cherry Supplementation in Metabolic Syndrome Patients
- Conditions
- Metabolic SyndromeHypertensionInsulin Resistance
- Registration Number
- NCT03615885
- Lead Sponsor
- University of Hertfordshire
- Brief Summary
The present study examined the effect of Montmorency tart cherry juice and capsules on functional and blood-based cardio-metabolic markers in humans with Metabolic Syndrome. Participants received a single bolus of Montmorency tart cherry juice, Montmorency tart cherry capsules and placebo in a random, crossover trial. Outcome variables were measured immediately pre- and up to 5 hours post-bolus. It was hypothesised that Montmorency tart cherry juice and capsules would improve cardio-metabolic markers. Furthermore, it was hypothesised that Montmorency tart cherry capsules would be more beneficial than Montmorency tart cherry juice due to increased bioavailability of phytochemicals.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 11
- Non-smoker,
Meet 3 of 5 criteria for Metabolic Syndrome based on National Cholesterol Education Program-Adult Treatment Panel III guidelines:
- Waist Circumference: >102cm (men), >88cm (women)
- Fasting Serum Triglycerides: ≥1.69 mmol.L-1
- Fasting High Density Lipoprotein: <1.03 mmol.L-1 (men), <1.29 mmol.L-1 (women)
- Blood Pressure: ≥130 mmHg SBP or ≥85 mmHg DBP
- Fasting Plasma Glucose: ≥6.1 mmol.L-1
- Current or previous history of gastrointestinal, cardiovascular, hepatic or renal disease, currently diagnosed with diabetes or uncontrolled hypertension (≥160/100 mmHg), allergy to maltodextrin or specific fruit products and those currently taking medication (such as steroids, NSAIDs, antibiotics, antihypertensive, hypoglycaemic, lipid-lowering drugs) or currently using any nutritional or antioxidant supplement. Heavy alcohol consumption (>14 units per week).
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Change in Fasting Insulin Pre-Bolus and Post-Bolus (1hr, 3hr, 5hr) Change in Systolic and Diastolic Blood Pressure Pre-Bolus and Post-Bolus (30min, 1hr, 2hr, 3hr, 4hr, 5hr) Change in Fasting Lipid Profile (Total Cholesterol, HDL, Triglycerides, LDL) Pre-Bolus and Post-Bolus (1hr, 3hr, 5hr) Change in Fasting Glucose Pre-Bolus and Post-Bolus (1hr, 3hr, 5hr)
- Secondary Outcome Measures
Name Time Method Change in Heart Rate Pre-Bolus and Post-Bolus (30min, 1hr, 2hr, 3hr, 4hr, 5hr) Beat-to-beat resting cardiac haemodynamics
Change in Augmentation Index Pre-Bolus and Post-Bolus (30min, 1hr, 2hr, 3hr, 4hr, 5hr) Measure of arterial stiffness and central blood pressures
Change in Cardiac Output Pre-Bolus and Post-Bolus (30min, 1hr, 2hr, 3hr, 4hr, 5hr) Beat-to-beat resting cardiac haemodynamics (cardiac output, mean arterial pressure, strove volume, total peripheral resistance, heart rate)
Change in Stroke Volume Pre-Bolus and Post-Bolus (30min, 1hr, 2hr, 3hr, 4hr, 5hr) Beat-to-beat resting cardiac haemodynamics
Change in Aortic Systolic and Diastolic Pressure Pre-Bolus and Post-Bolus (30min, 1hr, 2hr, 3hr, 4hr, 5hr) Measure of arterial stiffness and central blood pressures
Change in Mean Arterial Pressure Pre-Bolus and Post-Bolus (30min, 1hr, 2hr, 3hr, 4hr, 5hr) Beat-to-beat resting cardiac haemodynamics
Change in Resting Energy Expenditure Pre-Bolus and Post-Bolus (30min, 1hr, 2hr, 3hr, 4hr, 5hr) Measured from indirect calorimetry
Change in Augmentation Pressure Pre-Bolus and Post-Bolus (30min, 1hr, 2hr, 3hr, 4hr, 5hr) Measure of arterial stiffness and central blood pressures
Change in Total Peripheral Resistance Pre-Bolus and Post-Bolus (30min, 1hr, 2hr, 3hr, 4hr, 5hr) Beat-to-beat resting cardiac haemodynamics
Change in Respiratory Quotient Pre-Bolus and Post-Bolus (30min, 1hr, 2hr, 3hr, 4hr, 5hr) Measured from indirect calorimetry
Trial Locations
- Locations (1)
University of Hertfordshire
🇬🇧Hatfield, United Kingdom
University of Hertfordshire🇬🇧Hatfield, United Kingdom