Acute effects of capsaicin.

Recruiting

Conditions: Obesitas, overgewicht

Registration Number: NL-OMON29649

Lead Sponsor: McCormick and Maastricht University

Brief Summary: /A

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 16

Inclusion Criteria

A total of 16 subjects (8 males and 8 females) with BMI 20-30 kg/m2 and aged between 18-
50 years will be included in the study. All subjects will be healthy, non-smoking, not using a
more than moderate amount of alcohol (> 10 consumptions/wk) or caffeine-containing
beverages (> 2 cups/d), being weight stable (weight change < 3kg during the last 6 months),
dietary unrestraint and not using medication or supplements except for oral contraceptives in
women.

Exclusion Criteria

Subjects will be excluded if they are not healthy, smoking, using a more than moderate
amount of alcohol or caffeine-containing beverages, not being weight stable, dietary restraint, using medication or supplements except for oral contraceptives in women, or if they do not
meet the criteria for BMI and age. Pregnant and lactating women, and subjects with allergies
for the used food items will also be excluded from participation.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary endpoint of this study is the change in 36h energy expenditure.

Secondary Outcome Measures

Name	Time	Method
1. Substrate oxidation (fat and carbohydrates);<br /><br>2. Sleeping metabolic rate (SMR);<br /><br>3. Diet-induced thermogenesis (DIT);<br /><br>4. Activity induced thermogenesis (AEE);<br /><br>5. Substrate oxidation: carbohydrate, protein, respiratory quotient (RQ);<br /><br>6. Feelings of hunger and satiety: VAS for hunger, fullness, appetite, satiety, thirst, prospective food consumption, desire to eat;<br /><br>7. Ad libitum energy intake;<br /><br>8. Age;<br /><br>9. Body composition: body weight, BMI, body fat percentage, fat mass index (FMI);<br /><br>10. Body fat distribution: Waist circumference, waist-to-hip ratio (WHR).